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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/4966

    Título
    Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation
    Autor
    Villa Pérez, Pablo .
    Gallardo, Amalia B. .
    Díaz Marrero, Ana R. .
    Rosa, José M. de la .
    Croz, Luis D’ .
    Perdomo Hernández, Germán M.Autoridad UBU Orcid
    Cózar Castellano, Irene
    Darias, José .
    Cueto, Mercedes .
    Publicado en
    Marine Drugs. 2018, V. 16, n. 2, art. 49
    Editorial
    MDPI
    Fecha de publicación
    2018-02
    ISSN
    1660-3397
    DOI
    10.3390/md16020049
    Zusammenfassung
    Type 2 diabetes (T2DM) is a complex disease linked to pancreatic beta-cell failure and insulin resistance. Current antidiabetic treatment regimens for T2DM include insulin sensitizers and insulin secretagogues. We have previously demonstrated that leptolide, a member of the furanocembranolides family, promotes pancreatic beta-cell proliferation in mice. Considering the beneficial effects of leptolide in diabetic mice, in this study, we aimed to address the capability of leptolide to improve insulin resistance associated with the pathology of obesity. To this end, we tested the hypothesis that leptolide should protect against fatty acid-induced insulin resistance in hepatocytes. In a time-dependent manner, leptolide (0.1 µM) augmented insulin-stimulated phosphorylation of protein kinase B (PKB) by two-fold above vehicle-treated HepG2 cells. In addition, leptolide (0.1 µM) counteracted palmitate-induced insulin resistance by augmenting by four-fold insulin-stimulated phosphorylation of PKB in HepG2 cells. In vivo, acute intraperitoneal administration of leptolide (0.1 mg/kg and 1 mg/kg) improved glucose tolerance and insulin sensitivity in lean mice. Likewise, prolonged leptolide treatment (0.1 mg/kg) in diet-induced obese mice improved insulin sensitivity. These effects were paralleled with an ~50% increased of insulin-stimulated phosphorylation of PKB in liver and skeletal muscle and reduced circulating pro-inflammatory cytokines in obese mice. We concluded that leptolide significantly improves insulin sensitivity in vitro and in obese mice, suggesting that leptolide may be another potential treatment for T2DM
    Palabras clave
    Leptogorgia
    cembranolides
    furanocembranolides
    diketocembranolides
    seco-furanocembranolides
    chloro-furanocembranolides
    pancreatic beta-cells
    Materia
    Endocrinología
    Endocrinology
    URI
    http://hdl.handle.net/10259/4966
    Versión del editor
    https://doi.org/10.3390/md16020049
    Aparece en las colecciones
    • Artículos DIABO-TER
    Attribution 4.0 International
    Documento(s) sujeto(s) a una licencia Creative Commons Attribution 4.0 International
    Dateien zu dieser Ressource
    Nombre:
    Gallardo-md_2018.pdf
    Tamaño:
    963.4Kb
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