Synthesis of Tetrahydronaphthoazetidinones, 2,5‐Dioxo‐1,4‐methanobenzoazepines and 3‐Hydroxypyrrolidinones Through Copper‐Assisted Post‐Ugi Reactions

Abstract

Copper-assisted post-Ugi reactions enable access to different heterocyclic systems, tetrahydronaphthoazetidinone, 2,5-dioxo-1,4-methanobenzoazepine and 3-hydroxypyrrolidinone derivatives. The described process affords complex scaffolds from readily available acyclic precursors using simple protocols.