Stefano Marcaccini was one of the pioneers in the use of isocyanide-based multicomponent reactions in organic synthesis.
Throughout his career at the University of Florence he explored many diferent faces of isocyanide chemistry, especially
those geared towards the synthesis of biologically relevant heterocycles. His work inspired many researchers who contributed
to other important developments in the feld of multicomponent reactions and created a school of synthetic chemists that
continues today. In this manuscript we intend to review the articles on isocyanide multicomponent reactions published by
Dr. Marcaccini and analyse their infuence on the following works by other researchers. With this, we hope to highlight the
immense contribution of Stefano Marcaccini to the development of isocyanide chemistry and modern organic synthesis as
well as the infuence of his research on future generations. We believe that this review will not only be a well-deserved tribute
to the fgure of Stefano Marcaccini, but will also serve as a useful inspiration for chemists working in this feld.
