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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/8775

    Título
    Association Between Vitamin D Receptor rs731236 (Taq1) Polymorphism and Risk for Restless Legs Syndrome in the Spanish Caucasian Population
    Autor
    Jiménez Jiménez, Félix Javier
    García Martín, Elena
    Alonso Navarro, Hortensia
    Martínez, Carmen
    Zurdo, Martín
    Turpín Fenoll, Laura
    Millán Pascual, Jorge
    Adeva Bartolomé, Teresa
    Cubo Delgado, EstherUBU authority Orcid
    Navacerrada, Francisco
    Rojo Sebastián, Ana
    Rubio, Lluisa
    Ortega Cubero, Sara
    Pastor, Pau
    Calleja, Marisol
    Plaza Nieto, José Francisco
    Pilo de la Fuente, Belén
    Arroyo Solera, Margarita
    García Albea, Esteban
    Agúndez, José A. G.
    Publicado en
    Medicine. 2014, V. 94, n. 47, e2125
    Editorial
    Wolters Kluwer Health
    Fecha de publicación
    2015-11
    ISSN
    0025-7974
    DOI
    10.1097/MD.0000000000002125
    Abstract
    Several recent works suggest a possible role of vitamin D deficiency in the etiology or restless legs syndrome (RLS). We analyzed the possible relationship of 2 common single nucleotide polymorphisms (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS. We studied the genotype and allelic variant frequencies of VDR rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 healthy controls using a TaqMan essay. The frequencies of the rs731236AA genotype and the allelic variant rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively). Restless legs syndrome patients carrying the allelic variant rs731236G had an earlier age at onset, and those carrying the rs731236GG genotype had higher severity of RLS, although these data disappeared after multivariate analyses. None of the SNPs studied was related with the positivity of family history of RLS. These results suggest a modest, but significant association between VDR rs731236 SNP and the risk for RLS.
    Materia
    Sistema nervioso-Enfermedades
    Nervous system-Diseases
    Medicina
    Medicine
    URI
    http://hdl.handle.net/10259/8775
    Versión del editor
    https://journals.lww.com/md-journal/fulltext/2015/11240/association_between_vitamin_d_receptor_rs731236.57.aspx
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    Documento(s) sujeto(s) a una licencia Creative Commons Atribución 4.0 Internacional
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