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dc.contributor.author | Trigueros Andrés, Ester | |
dc.contributor.author | Benito Román, Oscar | |
dc.contributor.author | Oliveira, Andreia P. | |
dc.contributor.author | Videira, Romeu A. | |
dc.contributor.author | Andrade, Paula B. | |
dc.contributor.author | Sanz Díez, Mª Teresa | |
dc.contributor.author | Beltrán Calvo, Sagrario | |
dc.date.accessioned | 2024-03-08T08:01:31Z | |
dc.date.available | 2024-03-08T08:01:31Z | |
dc.date.issued | 2024-02 | |
dc.identifier.issn | 2076-3921 | |
dc.identifier.uri | http://hdl.handle.net/10259/8778 | |
dc.description.abstract | Onion skin waste (OSW), the primary non-edible byproduct from onion processing, offers a renewable source of bioactive compounds. This study aims to valorize OSW through subcritical water extraction (SWE), aligning with a circular economy and biorefinery principles. SWE was carried out at 145 °C and 50 bar for 50 min in a discontinuous reactor, producing a phenolic-rich extract (32.3 ± 2.6 mg/g) dominated by protocatechuic acid (20.3 ± 2.5 mg/g), quercetin-4′-O-glucoside (7.5 ± 0.2 mg/g), and quercetin (3.2 ± 0.6 mg/g). Additionally, the extract contains sugars (207.1 ± 20.3 mg sucrose-Eq/g), proteins (22.8 ± 1.6 mg BSA-Eq/g), and free amino acids (20.4 ± 1.2 mg arginine-Eq/g). Its phenolic richness determines its scavenging activity against ●NO and O2●− radicals and its α-glucosidase and aldose-reductase inhibition without affecting α-amylase. Notably, the extract demonstrates significant α-glucosidase inhibition (IC50 = 75.6 ± 43.5 µg/mL), surpassing acarbose (IC50 = 129.5 ± 1.0 µg/mL) in both pure enzyme and cell culture tests without showing cytotoxicity to AGS, HepG2, and Caco-2 human cell lines. The extract’s bioactivity and nutritional content make it suitable for developing antioxidant and antidiabetic nutraceutical/food components, highlighting SWE’s potential for OSW valorization without using organic solvents. | en |
dc.description.sponsorship | This research was funded by Portuguese national funds (Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project UIDP/50006/2020 of REQUIMTE/LAQV, and by the Spanish Agencia Estatal de Investigación [grant number PID2020-116716RJ-I00/AEI/10.13039/501100011033]. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Antioxidants. 2024, V. 13, n. 2, 205 | en |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Hydrothermal treatment | en |
dc.subject | Onion waste | en |
dc.subject | Polyphenols | en |
dc.subject | Quercetin | en |
dc.subject | Antioxidant activity | en |
dc.subject | Antidiabetic potential | en |
dc.subject.other | Ingeniería química | es |
dc.subject.other | Chemical engineering | en |
dc.title | Onion (Allium cepa L.) Skin Waste Valorization: Unveiling the Phenolic Profile and Biological Potential for the Creation of Bioactive Agents through Subcritical Water Extraction | en |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.relation.publisherversion | https://doi.org/10.3390/antiox13020205 | es |
dc.identifier.doi | 10.3390/antiox13020205 | |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116716RJ-I00/ES/TECNOLOGIAS DE FLUIDOS PRESURIZADOS PARA LA VALORIZACION DE SUBPRODUCTOS DE LA INDUSTRIA AGROALIMENTARIA: RECUPERACION DE PECTINA Y OTROS COMPUESTOS BIOACTIVOS DE ALTO VALOR/ | es |
dc.identifier.essn | 2076-3921 | |
dc.journal.title | Antioxidants | en |
dc.volume.number | 13 | es |
dc.issue.number | 2 | es |
dc.page.initial | 205 | es |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |