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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/9493

    Título
    Toxicology assessment of manganese oxide nanomaterials with enhanced electrochemical properties using human in vitro models representing different exposure routes
    Autor
    Fernández Pampín, NataliaUBU authority
    González Plaza, Juan JoséUBU authority Orcid
    García Gómez, Alejandra
    Peña, Elisa
    Rumbo Lorenzo, CarlosUBU authority Orcid
    Barros García, RocíoUBU authority Orcid
    Martel Martín, SoniaUBU authority Orcid
    Aparicio Martínez, SantiagoUBU authority Orcid
    Tamayo Ramos, Juan AntonioUBU authority Orcid
    Publicado en
    Scientific Reports. 2023, V. 12, n. 1
    Editorial
    Springer Nature
    Fecha de publicación
    2022-12-05
    DOI
    10.1038/s41598-022-25483-w
    Abstract
    In the present study, a comparative human toxicity assessment between newly developed Mn3O4 nanoparticles with enhanced electrochemical properties (GNA35) and their precursor material (Mn3O4) was performed, employing different in vitro cellular models representing main exposure routes (inhalation, intestinal and dermal contact), namely the human alveolar carcinoma epithelial cell line (A549), the human colorectal adenocarcinoma cell line (HT29), and the reconstructed 3D human epidermal model EpiDerm. The obtained results showed that Mn3O4 and GNA35 harbour similar morphological characteristics, whereas differences were observed in relation to their surface area and electrochemical properties. In regard to their toxicological properties, both nanomaterials induced ROS in the A549 and HT29 cell lines, while cell viability reduction was only observed in the A549 cells. Concerning their skin irritation potential, the studied nanomaterials did not cause a reduction of the skin tissue viability in the test conditions nor interleukin 1 alpha (IL- 1 α) release. Therefore, they can be considered as not irritant nanomaterials according to EU and Globally Harmonized System of Classification and Labelling Chemicals. Our findings provide new insights about the potential harmful effects of Mn3O4 nanomaterials with different properties, demonstrating that the hazard assessment using different human in vitro models is a critical aspect to increase the knowledge on their potential impact upon different exposure routes.
    Materia
    Química física
    Chemistry, Physical and theoretical
    URI
    http://hdl.handle.net/10259/9493
    Versión del editor
    https://doi.org/10.1038/s41598-022-25483-w
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