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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/9778

    Título
    Synthesis, Crystal Structure, Spectroscopic Characterization, DFT Calculations and Cytotoxicity Assays of a New Cu(II) Complex with an Acylhydrazone Ligand Derived from Thiophene
    Autor
    Rodríguez, María R.
    Balsa, Lucía M.
    Piro, Oscar Enrique
    Echeverría, Gustavo A.
    García Tojal, JavierAutoridad UBU Orcid
    Pis Diez, Reinaldo
    León, Ignacio E.
    Parajón Costa, Beatriz S.
    González Baró, Ana C.
    Publicado en
    Inorganics. 2021, V. 9, n. 2, p. 9
    Editorial
    MDPI
    Fecha de publicación
    2021-01
    DOI
    10.3390/inorganics9020009
    Abstract
    A new Cu(II) complex is synthetized by the reaction of copper nitrate and a N-acylhydrazone ligand obtained from the condensation of o-vanillin and 2-thiophecarbohydrazide (H2L). The solid-state structure of [Cu(HL)(H2O)](NO3)·H2O, or CuHL for simplicity, was determined by X-ray diffraction. In the cationic complex, the copper center is in a nearly squared planar environment with the nitrate interacting as a counterion. CuHL was characterized by spectroscopic techniques, including solid-state FTIR, Raman, electron paramagnetic resonance (EPR) and diffuse reflectance and solution UV-Vis electronic spectroscopy. Calculations based on the density functional theory (DFT) assisted the interpretation and assignment of the spectroscopic data. The complex does not show relevant antioxidant activity evaluated by the radical cation of 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) method, being even less active than the free ligand as a radical quencher. Cytotoxicity assays of CuHL against three human tumor cell lines, namely MG-63, A549 and HT-29, revealed an important enhancement of the effectiveness as compared with both the ligand and the free metal ion. Moreover, its cytotoxic effect was remarkably stronger than that of the reference metallodrug cisplatin in all cancer cell lines tested, a promissory result in the search for new metallodrugs of essential transition metals.
    Palabras clave
    Copper(II) complex
    N-acylhydrazone
    Spectroscopy
    XRD crystal structure
    DFT calculations
    Anti-cancer activity
    Materia
    Química inorgánica
    Chemistry, Inorganic
    URI
    http://hdl.handle.net/10259/9778
    Versión del editor
    https://doi.org/10.3390/inorganics9020009
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