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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/5225

    Título
    Toxicological response of the model fungus Saccharomyces cerevisiae to different concentrations of commercial graphene nanoplatelets
    Autor
    Suarez Diez, Maria
    Porras Alfonso, SantiagoUBU authority Orcid
    Laguna Teno, Félix
    Schaap, Peter J.
    Tamayo Ramos, Juan AntonioUBU authority Orcid
    Publicado en
    Scientific Reports. 2020, 10, art. 3232
    Editorial
    Nature Research
    Fecha de publicación
    2020-02
    DOI
    10.1038/s41598-020-60101-7
    Abstract
    Graphene nanomaterials have attracted a great interest during the last years for different applications, but their possible impact on different biological systems remains unclear. Here, an assessment to understand the toxicity of commercial polycarboxylate functionalized graphene nanoplatelets (GN) on the unicellular fungal model Saccharomyces cerevisiae was performed. While cell proliferation was not negatively affected even in the presence of 800 mg L−1 of the nanomaterial for 24 hours, oxidative stress was induced at a lower concentration (160 mg L−1), after short exposure periods (2 and 4 hours). No DNA damage was observed under a comet assay analysis under the studied conditions. In addition, to pinpoint the molecular mechanisms behind the early oxidative damage induced by GN and to identify possible toxicity pathways, the transcriptome of S. cerevisiae exposed to 160 and 800 mg L−1 of GN was studied. Both GN concentrations induced expression changes in a common group of genes (337), many of them related to the fungal response to reduce the nanoparticles toxicity and to maintain cell homeostasis. Also, a high number of genes were only differentially expressed in the GN800 condition (3254), indicating that high GN concentrations can induce severe changes in the physiological state of the yeast.
    Materia
    Materiales
    Materials
    URI
    http://hdl.handle.net/10259/5225
    Versión del editor
    https://doi.org/10.1038/s41598-020-60101-7
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    • Artículos ICCRAM
    Atribución 4.0 Internacional
    Documento(s) sujeto(s) a una licencia Creative Commons Atribución 4.0 Internacional
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