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Título : Inherent antibacterial activity and in vitro biocompatibility of hydrophilic polymer film containing chemically anchored sulfadiazine moieties
Autor : Morro, Ana
Abrusci, Concepción
Pablos, Jesús Luis
Marín, Irma
García García, Félix Clemente
García Pérez, José Miguel
Publicado en: European Polymer Journal. 2017, V. 91, p. 274–282
Editorial : Elsevier
Fecha de publicación : jun-2017
Fecha de disponibilidad: jun-2019
Resumen : Microbial colonisation of synthetic materials is a great concern in many fields, e.g., in implant surgery and medical devices; therefore biocompatible hydrophilic organic materials with inherent antimicrobial properties are of current research interest. In this work, we describe the preparation of antibacterial and biocompatible polymeric film based on N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl acrylate (HEA), using ethyleneglycol dimethacrylate (EGDMA), and synthetic acrylic monomer containing sulfadiazine chemically anchored. The synthesised polyvinylpyrrolidone (PVP)-based films were characterized by different techniques (1H and 13C NMR, ATR-FTIR, SEM, and TGA). In this study, the biophysical responses of bacteria and L929 cells towards the prepared materials as model device surfaces were evaluated. The membrane that contains the anchored sulfadiazine moiety showed excellent antibacterial activity against Escherichia coli as well as good biocompatibility. Based on the experimental results, this material is a good candidate for medical applications as a biomaterial.
Palabras clave: PVP
Sulfadiazine
Antibacterial polymer
Biocompatible
URI : http://hdl.handle.net/10259/4436
Versión del editor: https://doi.org/10.1016/j.eurpolymj.2017.04.012
Aparece en las colecciones: Artículos POLYMERS

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