The Safe and Sustainable-by-Design (SSbD) framework by the EC-JRC (European Commission – Joint Research
Centre) provides a structured approach to integrate safety and sustainability considerations from the earliest
stages of chemical and material innovation. However, applying SSbD principles to advanced materials poses
specific challenges due to their complex and diverse physicochemical properties. This work analyzes and maps
hazard, exposure, fate and risk assessment methods and tools applicable to Steps 1, 2 and 3 of the EC-JRC SSbD
framework, categorizing them across its three tiers to address different stages of product development. The
analysis highlights the challenges of adapting conventional testing and modelling approaches to advanced materials, particularly for hazard assessment, and considers the relevance and limitations of tools originally
developed for exposure and risk assessment of engineered nanomaterials when applied to broader advanced
materials categories. An assessment of operational status, access conditions, and tool formats provides practical
insights for researchers and industry stakeholders. The study identifies key methodological gaps and offers
recommendations to improve and expand the current tool landscape. By providing a structured mapping of
available resources and challenges, this work supports the effective implementation of SSbD principles, promoting the safe and sustainable development of advanced materials
