Olive oil and lycopene are foods that have potent antioxidant activity. The objective was
to determine the effects of consumption of olive oil enriched with lycopene on oxidative stress
biomarkers in hypercholesterolemic subjects. We examined the effects of oil enriched with lycopene
extract daily intake during 1 month on plasma antioxidant capacity, lipids profile (triacylgycerols, total
cholesterol, cHDL; cLDL, ox-LDL), biomarkers of oxidative stress, and inflammatory markers related
with atherosclerosis risk (C-reactive protein (CRP), IL-6; sDC4L) in subjects hypercholesteremics
(cholesterol > 220 mg/dL). In the group consuming olive oil-lycopene, significant increases (p < 0.05)
in the levels of plasma lycopene concentration (0.146 ± 0.03 versus 0.202 ± 0.04 (µmol/L)), α-carotene
(0.166 ± 0.064 versus 0.238 ± 0.07) and in β-carotene (0.493 ± 0.187 versus 0.713 ± 0.221) were
observed. These results are linked with the increases of plasma antioxidants and decreases biomarkers
of oxidative stress (carbonyl groups, malondialdehyde and 8-hydroxy-deoxiguanosine) observed
in hypercholesterolemic group. In relation to lipid profile, a significant decrease was observed
in the levels of ox-LDL (781 ± 302 versus 494 ± 200), remaining unchanged the levels of TG,
cholesterol, HDL and LDL-c. Regarding inflammatory biomarkers, the levels of CRP and IL-6
decreased significantly. The positive results obtained in this study support the use of olive oil
enriched with lycopene to reduce the risk of coronary disease.
