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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/8051

    Título
    Biomarkers of Oxidative Stress in Healthy Infants within the First Three Days after Birth
    Autor
    Cavia Saiz, MónicaAutoridad UBU Orcid
    Arnaez, Juan
    Cilla, Amaia
    Puente, Laura
    García-Miralles, Laura C.
    Muñiz Rodríguez, PilarAutoridad UBU Orcid
    Publicado en
    Antioxidants. 2023, V. 12, n. 6, 1249
    Editorial
    MDPI
    Fecha de publicación
    2023-06
    DOI
    10.3390/antiox12061249
    Abstract
    The clinical relevance of stress biomarkers in newborns is well established. Currently, oxidative stress (OS) parameters are seen to play an important role in neonatal resuscitation guidelines, and a link has been observed between the amount of oxygen delivered and the level of OS and the development of various pathologies. The aim of the current study was to investigate changes in neonatal plasma and urine OS status during the first hours after birth. A lower antioxidant capacity (TAC) and higher levels of malondialdehyde in blood were observed in newborns at the time of birth compared with results 48 h postnatally. The urine revealed a significant and progressive increase in TAC and creatinine during the first 36 h of life, with a progressive decline thereafter. Meanwhile, malondialdehyde in urine samples showed no significant differences over time. Overall, the correlation between blood and urine parameters was poor, except for the relationship between umbilical vein glutathione reduced/oxidized ratio and urine malondialdehyde (r = 0.7; p = 0.004) and between TAC in the umbilical artery and urine (r = −0.547; p = 0.013). The biomarkers evaluated in this study could be established as reference values for neonatal OS.
    Palabras clave
    Oxidative stress
    Infant
    Birth
    Cord blood
    Glutathione
    Malondialdehyde
    Carbonyl
    Creatinine
    Materia
    Alimentos
    Food
    Biología molecular
    Molecular biology
    Bioquímica
    Biochemistry
    URI
    http://hdl.handle.net/10259/8051
    Versión del editor
    https://doi.org/10.3390/antiox12061249
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