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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/8072

    Título
    TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status
    Autor
    Herreros-Villanueva, Marta
    Muñiz Rodríguez, PilarAutoridad UBU Orcid
    García Girón, Carlos
    Cavia Saiz, MónicaAutoridad UBU Orcid
    Coma del Corral, María J.
    Publicado en
    Journal of Translational Medicine. 2010, V. 8, n. 1
    Editorial
    Springer Nature
    Fecha de publicación
    2010-02
    DOI
    10.1186/1479-5876-8-15
    Resumo
    Background: Although there have been many studies on the p73 gene, some of its functions still remain unclear. There is little research on the relationship between p73 gene transcription and its protein expression and the response to certain drugs such as oxaliplatin and cetuximab, which are drugs currently used in colorectal cancer. The purpose of this study was to evaluate the impact of TAp73 expression on oxaliplatin and cetuximab-based chemotherapy in colorectal cancer cell lines with different K-Ras and B-Raf mutational status. Methods: TAp73 was analyzed in three colorectal tumor cell lines HT-29, SW-480 and Caco-2. mRNA TAp73 was determined using Real time PCR; TAp73 protein by immunoblotting and cell viability was analyzed by the MTT method. Results: We found that mRNA and TAp73 protein were decreased in cells treated with oxaliplatin (in monotherapy or combined with cetuximab) when B-Raf is mutated. This was statistically significant and was also associated with higher cell viability after the treatment. Conclusions: Here, for the first time we report, that there is a signaling loop between B-Raf activation and p73 function. Low expression of TAp73 in colorectal cancer cell lines with mutated B-Raf may be involved in the lack of response to oxaliplatin in monotherapy or combined with cetuximab.
    Materia
    Salud
    Health
    Biología molecular
    Molecular biology
    URI
    http://hdl.handle.net/10259/8072
    Versión del editor
    https://doi.org/10.1186/1479-5876-8-15
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    Attribution 3.0 Unported
    Documento(s) sujeto(s) a una licencia Creative Commons Attribution 3.0 Unported
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    Herreros-jtm_2010.pdf
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