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dc.contributor.authorGuilarte Moreno, Verónica 
dc.contributor.authorCastroviejo Fernández, Mª Pilar 
dc.contributor.authorGarcía García, Patricia
dc.contributor.authorFernández Rodríguez, Manuel A. 
dc.contributor.authorSanz Díez, Roberto 
dc.date.accessioned2016-01-27T09:24:07Z
dc.date.available2016-01-27T09:24:07Z
dc.date.issued2011-03
dc.identifier.issn0022-3263
dc.identifier.urihttp://hdl.handle.net/10259/3913
dc.description.abstract2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.en
dc.description.sponsorshipMinisterio de Ciencia e Innovacion (MICINN) and FEDER (CTQ2010-15358) and Junta de Castilla y Leon (BU021A09 and GR-172) for financial support. V.G. thanks Ministerio de Educacion y Ciencia for a MEC-FPU predoctoral fellowship. P.G.-G. and M.A.F.-R. thank MICINN for "Juan de la Cierva" and "Ramon y Cajal" contracts.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherAmerican Chemical Societyen
dc.relation.ispartofJournal of organic chemistry. 2010. V. 76, n. 9, p. 3416–3437en
dc.subject.otherQuímica orgánicaes
dc.subject.otherChemistry, Organicen
dc.titleApproaches to the Synthesis of 2,3-Dihaloanilines. Useful Precursors of 4-Functionalized-1H-indoles§en
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.description.versionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of organic chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttp://dx.doi.org/10.1021/jo200406f
dc.identifier.doi10.1021/jo200406f
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN-FEDER/CTQ2010-15358
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU021A09
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/GR-172
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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