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dc.contributor.authorGil García, Rubén 
dc.contributor.authorUgalde, María 
dc.contributor.authorBusto Vázquez, Natalia 
dc.contributor.authorLozano Ordóñez, Héctor J.
dc.contributor.authorLeal Villalba, José María 
dc.contributor.authorPérez, Begoña 
dc.contributor.authorMadariaga, Gotzon .
dc.contributor.authorInsausti, Maite
dc.contributor.authorLezama, Luis .
dc.contributor.authorSanz Díez, Roberto 
dc.contributor.authorGómez Sainz, Lidia M. 
dc.contributor.authorGarcía Ruiz, Begoña 
dc.contributor.authorGarcía Tojal, Javier 
dc.date.accessioned2016-11-24T08:30:17Z
dc.date.available2017-12-07T03:45:06Z
dc.date.issued2016-12
dc.identifier.issn1477-9226
dc.identifier.urihttp://hdl.handle.net/10259/4282
dc.description.abstractThiosemicarbazones and their metal derivatives have long been screened as antitumor agents, and their interactions with DNA have been analysed. Herein, we describe the synthesis and characterization of compounds containing [CuL]+ entities (HL = pyridine-2-carbaldehyde thiosemicarbazone) and adenine, cytosine or 9-methylguanine, and some of their corresponding nucleotides. For the first time, crystal structures of adenine- and 9-methylguanine-containing thiosemicarbazone complexes are reported. To the best of our knowledge, the first study on the affinity thiosemicarbazone–RNA is also provided here. Experimental and computational studies have shown that [CuL(OH2)]+ entities at low concentration intercalate into dsRNA poly(rA)·poly(rU) through strong hydrogen bonds involving uracil residues and π–π stacking interactions. In fact, noncovalent interactions are present both in the solid state and in solution. This behaviour diverges from that observed with DNA duplexes and creates an optimistic outlook in achieving selective binding to RNA for subsequent possible medical applications.en
dc.description.sponsorshipObra Social “la Caixa” (OSLC-2012-007), Ministerio de Economía y Competitividad and FEDER funds (CTQ2013-48937-C2-1-P, CTQ2015-70371- REDT, MAT2012-34740 and CTQ2014-58812-C2-2-R), Junta de Castilla y León (BU237U13), the Basque Government (IT-779- 13), Gerencia Regional de Salud, Consejería de Sanidad, Junta de Castilla y León (GRS 1023/A/14 and GR172).en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofDalton transactions, 2016, n. 45, p. 45, 18704-18718en
dc.titleSelectivity of a thiosemicarbazonatocopper(II) complex towards duplex RNA. Relevant noncovalent interactions both in solid state and solutionen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttp://dx.doi.org/10.1039/C6DT02907H
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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