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dc.contributor.authorSuárez, Anisley 
dc.contributor.authorMartínez Lara, Fernando 
dc.contributor.authorSanz Díez, Roberto 
dc.date.accessioned2016-12-01T10:00:54Z
dc.date.available2017-12-21T03:45:06Z
dc.date.issued2016-12
dc.identifier.issn1477-0520
dc.identifier.urihttp://hdl.handle.net/10259/4288
dc.description.abstractA new and efficient synthesis of α-functionalized α-indol-3-yl ketones from easily available indolyl α-acyloins is reported. This process, catalyzed by Brønsted or Lewis acids, involves an uncommon direct nucleophilic substitution reaction of a secondary α-carbonyl-substituted hydroxyl group. The described methodology allows the introduction of a variety of nucleophiles such as (hetero)arenes, thiophenols, nitroanilines and 1,3-dicarbonyl derivatives. The synthesized α-indol-3-yl carbonyl compounds are important synthetic targets also useful for accessing functionalized tryptophols and furan-3-yl indoles.en
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO) (CTQ2013-48937-C2-1-P) and Junta de Castilla y León and FEDER (BU237U13 and BU076U16)en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofOrganic & Biomolecular Chemistry. 2016, V. 14, n. 47, p. 11212-11219en
dc.subject.otherQuímica orgánicaes
dc.subject.otherChemistry, Organicen
dc.titleSynthesis of α-functionalized α-indol-3-yl carbonyls through direct SN reactions of indol-3-yl α-acyloinsen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttp://dx.doi.org/10.1039/c6ob02125e
dc.identifier.doi10.1039/c6ob02125e
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2013-48937-C2-1-P
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL-FEDER/BU237U13
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL-FEDER/BU076U16
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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