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dc.contributor.authorFernández Natal, Isabel
dc.contributor.authorSáez Nieto, J. A.
dc.contributor.authorRodríguez Lázaro, David 
dc.contributor.authorValdezate Ramos, S.
dc.contributor.authorParras Padilla, T.
dc.contributor.authorMedina, M. J.
dc.contributor.authorRodríguez Pollán, R. H.
dc.contributor.authorBlom, J.
dc.contributor.authorTauch, A.
dc.contributor.authorSoriano, F.
dc.date.accessioned2017-03-29T09:34:05Z
dc.date.available2017-03-29T09:34:05Z
dc.date.issued2016-03
dc.identifier.urihttp://hdl.handle.net/10259/4392
dc.description.abstractDuring a 12-year period we isolated five Corynebacterium argentoratense strains identified by phenotypic methods, including the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) and 16S rRNA gene sequencing. In addition, antimicrobial susceptibility was determined, and genome sequencing for the detection of antibiotic resistance genes was performed. The organisms were isolated from blood and throat cultures and could be identified by all methods used. All strains were resistant to cotrimoxazole, and resistance to β-lactams was partly present. Two strains were resistant to erythromycin and clindamycin. The draft genome sequences of theses isolates revealed the presence of the erm(X) resistance gene that is embedded in the genetic structure of the transposable element Tn5423. Although rarely reported as a human pathogen, C. argentoratense can be involved in bacteraemia and probably in other infections. Our results also show that horizontal transfer of genes responsible for antibiotic resistance is occurring in this species.en
dc.description.sponsorshipSupported in part by the Gerencia Regional de Salud, Junta de Castilla y León, Spain (research project GRS 698/A/2011)en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieren
dc.relation.ispartofNew Microbes and New Infections. 2016, V. 10, p. 116–121en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAntimicrobial resistanceen
dc.subjectclinical infectionsen
dc.subjectCorynebacterium argentoratenseen
dc.subjectMALDI-TOFen
dc.subjectwhole genome sequencingen
dc.titlePhenotypic, molecular characterization, antimicrobial susceptibility and draft genome sequence of Corynebacterium argentoratense strains isolated from clinical samplesen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.nmni.2016.01.007
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionen


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