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dc.contributor.authorFernández Natal, Isabel
dc.contributor.authorRodríguez Lázaro, David 
dc.contributor.authorMarrodán Ciordia, T.
dc.contributor.authorSáez Nieto, J. A.
dc.contributor.authorValdezate Ramos, S.
dc.contributor.authorRodríguez Pollán, R. H.
dc.contributor.authorTauch, A.
dc.contributor.authorSoriano, F.
dc.date.accessioned2017-03-30T11:34:29Z
dc.date.available2017-03-30T11:34:29Z
dc.date.issued2016-11
dc.identifier.urihttp://hdl.handle.net/10259/4398
dc.description.abstractHuman infections associated with Corynebacterium kroppenstedtii are rarely reported, and this organism is usually described as antibiotic sensitive. Almost all published cases of C. kroppenstedtii infections have been associated with breast pathology in women and have been described in New Zealand, France, Canada, India and Japan. Here we describe the microbiologic characteristics of two strains isolated from two women diagnosed of granulomatous mastitis in Spain. One C. kroppenstedtii isolate was antibiotic sensitive while the other was multidrug resistant. Biochemical identification was possible using a wide battery of methods including API Coryne V2.0, API Strep, API NH, API NE, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene amplification and sequencing. Antimicrobial susceptibility to 28 antibiotics as determined by Etest showed one isolate being sensitive to benzylpenicillin, ciprofloxacin, moxifloxacin, gentamicin, vancomycin, clindamycin, tetracycline, linezolid and rifampin. The second isolate showed resistance to ciprofloxacin, moxifloxacin, clindamycin, tetracycline and rifampin. The multidrug-resistant isolate contained the erm(X), tet(W), cmx, aphA1-IAB, strAB and sul1 resistance genes known from the R plasmid pJA144188 of Corynebacterium resistens. These genes were absent in the genome of the antibiotic-sensitive isolate. This report confirms the tropism of this microorganism for women's breasts and presents the first description of a multidrug-resistant C. kroppenstedtii strain.en
dc.description.sponsorshipGerencia Regional de Salud, Junta de Castilla y León, Spain, research project GRS 698/A/2011en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieren
dc.relation.ispartofNew Microbes and New Infections. 2016, V. 14, p. 93–97en
dc.subjectAntimicrobial susceptibilityen
dc.subjectCorynebacterium kroppenstedtiien
dc.subjectgranulomatous mastitisen
dc.subjectMALDI-TOF MSen
dc.subjectmultidrug-resistant isolateen
dc.titleCharacterization and antimicrobial susceptibility of one antibiotic-sensitive and one multidrug-resistant Corynebacterium kroppenstedtii strain isolated from patients with granulomatous mastitisen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.nmni.2016.09.006
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionen


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