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dc.contributor.authorAriza Miguel, Jaime
dc.contributor.authorJohansson, Anders
dc.contributor.authorFernández Natal, Isabel
dc.contributor.authorMartínez Nistal, Carmen
dc.contributor.authorOrduña, Antonio
dc.contributor.authorRodríguez Ferri, F.
dc.contributor.authorHernández Pérez, Marta 
dc.contributor.authorRodríguez Lázaro, David 
dc.date.accessioned2017-04-07T08:39:09Z
dc.date.available2017-04-07T08:39:09Z
dc.date.issued2014-05
dc.identifier.urihttp://hdl.handle.net/10259/4411
dc.description.abstractTularemia outbreaks occurred in northwestern Spain in 1997–1998 and 2007–2008 and affected >1,000 persons. We assessed isolates involved in these outbreaks by using pulsed-field gel electrophoresis with 2 restriction enzymes and multilocus variable number tandem repeat analysis of 16 genomic loci of Francisella tularensis, the cause of this disease. Isolates were divided into 3 pulsotypes by pulsed-field gel electrophoresis and 8 allelic profiles by multilocus variable number tandem repeat analysis. Isolates obtained from the second tularemia outbreak had the same genotypes as isolates obtained from the first outbreak. Both outbreaks were caused by genotypes of genetic subclade B.Br:FTNF002–00, which is widely distributed in countries in central and western Europe. Thus, reemergence of tularemia in Spain was not caused by the reintroduction of exotic strains, but probably by persistence of local reservoirs of infection.en
dc.description.sponsorshipproject PEP 2009/1422 of the Junta de Castilla y León (Spain).en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherCenters for Disease Control and Preventionen
dc.relation.ispartofEmerging Infectious Diseases. 2014, V. 20, n. 5, p. 754-761en
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleMolecular Investigation of Tularemia Outbreaks, Spain, 1997–2008en
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://dx.doi.org/10.3201/eid2005.130654
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionen


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