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dc.contributor.authorGarcía García, Patricia
dc.contributor.authorSanjuán Cortázar, Ana María 
dc.contributor.authorRashid, Muhammad A. 
dc.contributor.authorMartínez Cuezva, Alberto 
dc.contributor.authorFernández Rodríguez, Manuel A. 
dc.contributor.authorRodríguez, Félix
dc.contributor.authorSanz Díez, Roberto 
dc.date.accessioned2017-07-13T11:36:37Z
dc.date.available2018-01-20T03:45:07Z
dc.date.issued2017-01
dc.identifier.issn0022-3263
dc.identifier.urihttp://hdl.handle.net/10259/4530
dc.description.abstractA convenient method for the preparation of synthetically useful 3- iodoindene derivatives has been developed. This protocol, based on the 5-endo iodocyclization reaction of o-(alkynyl)styrenes, represents one of the scarce examples of halocyclizations using olefins as nucleophilic counterparts and allows the synthesis of both 3-iodo-1H-indenes (from β-alkyl-β-alkyl/aryl-o-(alkynyl)styrenes) and 3-iodobenzofulvenes (from β,β-diaryl-o-(alkynyl)styrenes) in good yields under mild reaction conditions. In addition, related alkoxyiodocyclization processes are described, which are particularly interesting in their intramolecular version because they allow the synthesis of heteropolycyclic structures containing the indene core. Finally, the usefulness of the prepared 3-iodoindenes has been demonstrated by the synthesis of several polysubstituted indene derivatives through conventional palladium-catalyzed cross-coupling reactions and iodine−lithium exchange processes.en
dc.description.sponsorshipMinisterio de Economiá y Competitividad (MINECO) and FEDER (CTQ2013-48937- C2-1P) and Junta de Castilla y León (BU237U13 and BU076U16)en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherAmerican Chemical Societyen
dc.relation.ispartofJOC, Journal of Organic Chemistry. 2017, V. 82, n. 2, p. 1155–1165en
dc.subject.otherQuímica orgánicaes
dc.subject.otherChemistry, Organicen
dc.titleSynthesis of Functionalized 1H-Indenes and Benzofulvenes through Iodocyclization of o-(Alkynyl)styrenesen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttp://dx.doi.org/10.1021/acs.joc.6b02788
dc.identifier.doi10.1021/acs.joc.6b02788
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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