Mostrar el registro sencillo del ítem
dc.contributor.author | Pertejo Fernández, Pablo | |
dc.contributor.author | Corres, Nazaret | |
dc.contributor.author | Torroba Pérez, Tomás | |
dc.contributor.author | García Valverde, María | |
dc.date.accessioned | 2017-07-27T11:07:43Z | |
dc.date.available | 2017-07-27T11:07:43Z | |
dc.date.issued | 2015-02-06 | |
dc.identifier.issn | 1523-7060 | |
dc.identifier.uri | http://hdl.handle.net/10259/4543 | |
dc.description.abstract | Enantiopure 3-carboxamide-1,4-benzodiazepin-5-ones were synthesized via the Ugi reaction followed by the Staudinger/aza-Wittig or reduction reactions in only two steps. A complete reversal of diastereoselectivity was achieved depending on the cyclization methodology employed. The different orientation of the C3 substituent in our 3-substituted 1,4-benzodiazepin-5-ones with respect to the most studied 1,4-benzodiazepin-2-ones makes them complementary in the development of new drugs because the primary source of binding selectivity of 1,4-benzodiazepines is the selective recognition of ligand conformations by the receptor. | en |
dc.description.sponsorship | Ministerio de Economía y Competitividad, Spain (Project CTQ2012-31611), Junta de Castilla y León, Consejería de Educación y Cultura y Fondo Social Europeo (Project BU246A12-1) and the European Commission, Seventh Framework Programme (Project SNIFFER FP7-SEC-2012-312411). | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | es |
dc.publisher | American Chemical Society | en |
dc.relation.ispartof | Organic Letters. 2015, V. 17, n. 3, p. 612–615 | en |
dc.subject.other | Chemistry, Organic | en |
dc.subject.other | Química orgánica | es |
dc.title | Reversal of diastereoselectivity in the synthesis of Peptidomimetic 3‑Carboxamide-1,4-benzodiazepin-5-ones | en |
dc.type | info:eu-repo/semantics/article | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.relation.publisherversion | http://dx.doi.org/10.1021/ol503628r | |
dc.identifier.doi | 10.1021/ol503628r | |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/312411 | |
dc.type.hasVersion | info:eu-repo/semantics/acceptedVersion | en |