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dc.contributor.authorGarcía Tojal, Javier 
dc.contributor.authorGil García, Rubén 
dc.contributor.authorFouz Cuesta, Víctor Ivo 
dc.contributor.authorMadariaga, Gotzon
dc.contributor.authorLezama, Luis
dc.contributor.authorGalletero, María S.
dc.contributor.authorBorrás, Joaquín
dc.contributor.authorNollmann, Friederike I.
dc.contributor.authorGarcía Girón, Carlos
dc.contributor.authorAlcaraz, Raquel
dc.contributor.authorCavia Saiz, Mónica 
dc.contributor.authorMuñiz Rodríguez, Pilar 
dc.contributor.authorPalacios, Òscar
dc.contributor.authorSamper, Katia G.
dc.contributor.authorRojo, Teófilo
dc.date.accessioned2018-09-10T08:48:17Z
dc.date.issued2018-03
dc.identifier.issn0162-0134
dc.identifier.urihttp://hdl.handle.net/10259/4929
dc.description.abstractThiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands.en
dc.description.sponsorshipObra Social “la Caixa” (OSLC-2012-007), Ministerio de Economía y Competitividad and FEDER funds (CTQ2013-48937-C2-1-P, CTQ2015-70371-REDT, MAT2015-66441-P, BIO2015-67358-C2-2-P), Junta de Castilla y León (BU237U13), Gerencia Regional de Salud, Consejería de Sanidad, Junta de Castilla y León (GRS 1023/A/14), the Basque Government (project IT-779-13)en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieren
dc.relation.ispartofJournal of Inorganic Biochemistry. 2018, V. 180, p. 69–79en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectColon carcinomaen
dc.subjectCopperen
dc.subjectMolecular magnetismen
dc.subjectThiosemicarbazoneen
dc.subject.otherQuímica inorgánicaes
dc.subject.otherChemistry, Inorganicen
dc.subject.otherAparato digestivo-Enfermedadeses
dc.subject.otherDigestive organs-Diseasesen
dc.titleRevisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell linesen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.date.embargo2020-04
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1016/j.jinorgbio.2017.12.005
dc.identifier.doi10.1016/j.jinorgbio.2017.12.005
dc.relation.projectIDinfo:eu-repo/grantAgreement/FundaciónLaCaixa/ OSLC-2012-007
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2013-48937-C2-1-P
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2015-70371-REDT
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2015-66441-P
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/BIO2015-67358-C2-2-P
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU237U13
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/GRS 1023/A/14
dc.relation.projectIDinfo:eu-repo/grantAgreement/GV/IT-779-13
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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