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dc.contributor.authorGarcía Tojal, Javier 
dc.contributor.authorGil García, Rubén 
dc.contributor.authorFouz Cuesta, Víctor Ivo 
dc.contributor.authorMadariaga, Gotzon .
dc.contributor.authorLezama, Luis .
dc.contributor.authorGalletero, María S. .
dc.contributor.authorBorrás, Joaquín .
dc.contributor.authorNollmann, Friederike I. .
dc.contributor.authorGarcía Girón, Carlos .
dc.contributor.authorAlcaraz, Raquel .
dc.contributor.authorCavia Saiz, Mónica 
dc.contributor.authorMuñiz Rodríguez, Pilar 
dc.contributor.authorPalacios, Òscar .
dc.contributor.authorSamper, Katia G. .
dc.contributor.authorRojo, Teófilo .
dc.date.accessioned2018-09-10T08:48:17Z
dc.date.issued2018-03
dc.identifier.issn0162-0134
dc.identifier.urihttp://hdl.handle.net/10259/4929
dc.description.abstractThiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands.en
dc.description.sponsorshipObra Social “la Caixa” (OSLC-2012-007), Ministerio de Economía y Competitividad and FEDER funds (CTQ2013-48937-C2-1-P, CTQ2015-70371-REDT, MAT2015-66441-P, BIO2015-67358-C2-2-P), Junta de Castilla y León (BU237U13), Gerencia Regional de Salud, Consejería de Sanidad, Junta de Castilla y León (GRS 1023/A/14), the Basque Government (project IT-779-13)en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieren
dc.relation.ispartofJournal of Inorganic Biochemistry. 2018, V. 180, p. 69–79en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectColon carcinomaen
dc.subjectCopperen
dc.subjectMolecular magnetismen
dc.subjectThiosemicarbazoneen
dc.subject.otherQuímica inorgánicaes
dc.subject.otherChemistry, Inorganicen
dc.subject.otherAparato digestivo-Enfermedadeses
dc.subject.otherDigestive organs-Diseasesen
dc.titleRevisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell linesen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.date.embargo2020-04
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1016/j.jinorgbio.2017.12.005
dc.identifier.doi10.1016/j.jinorgbio.2017.12.005
dc.relation.projectIDinfo:eu-repo/grantAgreement/FundaciónLaCaixa/ OSLC-2012-007
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2013-48937-C2-1-P
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2015-70371-REDT
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2015-66441-P
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/BIO2015-67358-C2-2-P
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU237U13
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/GRS 1023/A/14
dc.relation.projectIDinfo:eu-repo/grantAgreement/GV/IT-779-13
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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