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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/5200

    Título
    Synthesis, characterization, DFT calculations and anticancer activity of a new oxidovanadium(iv) complex with a ligand derived from o-vanillin and thiophene
    Autor
    Rodríguez, María R.
    Balsa, Lucía M.
    Plá, Julián del
    García Tojal, JavierUBU authority Orcid
    Pis Diez, Reinaldo
    Parajón Costa, Beatriz S.
    León, Ignacio E.
    González Baró, Ana C.
    Publicado en
    New Journal of Chemistry. 2019, V. 43, n. 29, p. 11784-11794
    Editorial
    Royal Society of Chemistry
    Fecha de publicación
    2019
    ISSN
    1144-0546
    DOI
    10.1039/C9NJ02092F
    Abstract
    From the interaction of the vanadyl ion with a ligand (HL), obtained by the condensation reaction of o-vanillin and 2-thiophenemethylamine, an oxidovanadium(IV) complex (VOL2) was obtained. It was characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance, and UV-vis and EPR, in solution. Its thermal behavior was analyzed by means of TGA and DTA. Theoretical studies based on DFT computational methods aided in the interpretation and assignment of spectroscopic data. Cytotoxicity assays (48 h) against bone cancer cells (MG-63, IC50 = 50.4 ± 8.7), breast cancer cells (MCF-7, IC50 = 42.3 ± 4.7), (MDA-MB-231, IC50 = 29.0 ± 1.7) and a normal fibroblast (L929, IC50 = 71.0 ± 3.5) demonstrated the enhancement of the effectiveness and selectivity of the complex as compared with both the ligand and the free metal ion. Besides, the compound inhibits cell migration, increases ROS levels and facilitates apoptosis. On a whole, these results show the main mechanisms of the deleterious effects of [VOL2] in a triple negative breast cancer cell line (MDA-MB-231), demonstrating that this complex is a promising therapeutic agent for this kind of breast cancer.
    Materia
    Química inorgánica
    Chemistry, Inorganic
    URI
    http://hdl.handle.net/10259/5200
    Versión del editor
    https://doi.org/10.1039/C9NJ02092F
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