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dc.contributor.authorRodríguez, María R.
dc.contributor.authorPlá, Julián del
dc.contributor.authorBalsa, Lucía M.
dc.contributor.authorLeón, Ignacio E.
dc.contributor.authorPiro, Oscar Enrique
dc.contributor.authorEcheverría, Gustavo A.
dc.contributor.authorGarcía Tojal, Javier 
dc.contributor.authorPis Diez, Reinaldo
dc.contributor.authorParajón Costa, Beatriz S.
dc.contributor.authorGonzález Baró, Ana C.
dc.date.accessioned2020-01-08T12:44:58Z
dc.date.available2020-01-08T12:44:58Z
dc.date.issued2019-05
dc.identifier.issn1144-0546
dc.identifier.urihttp://hdl.handle.net/10259/5201
dc.description.abstractThe interaction of a poly-functional ligand derived from o-vanillin and 2-thiophenemethylamine (oVATPNH2) with transition metal ions Cu(II) and Zn(II) leads to the formation of stable coordination compounds, namely [Cu(oVATPNH2)2] and [Zn(oVATPNH2)2]. Their crystal structures have been determined by X-ray diffraction methods. Two molecules of the deprotonated ligand acting in a bidentate fashion build a nearly square planar environment around Cu(II) and a distorted tetrahedral coordination arrangement for Zn(II). The complexes were characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance and solution UV-vis and EPR. Their thermal behavior has been analyzed by means of TGA and DTA. DFT theoretical studies, using computational methods based on DFT, were employed to assist the interpretation and assignment of spectroscopic data. Cytotoxicity assays against two human breast cancer cell lines, namely MCF-7 and MDA-MB-231, revealed an enhancement of the effectiveness of the complexes as compared with both the ligand and the free metal ions. The results for the copper compound are promising, as its cytotoxic effect was stronger than the reference metallodrug cisplatin in both cancer cell lines tested.en
dc.description.sponsorshipCONICET-CCT-La Plata (PIP 0651 and 0034), ANPCyT (PICT 2016-1574) and UNLP (11/X-473) (Argentina) and also by Consejerı´a de Educacio´n CyL and FFEDER BU076U16, BU022G18 and Ministerio de Economı´a y Competitividad CTQ2016-75023-C2-1-P and CTQ2015-70371- REDT MetDrugs Network (Spain
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofNew Journal of Chemistry. 2019, V. 43, n. 18, p. 7120-7129
dc.subject.otherQuímica inorgánicaes
dc.subject.otherChemistry, Inorganicen
dc.titleCu(ii) and Zn(ii) complexes with a poly-functional ligand derived from o-vanillin and thiophene. Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cellsen
dc.typeinfo:eu-repo/semantics/article
dc.typeArtículoes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1039/C8NJ06274A
dc.identifier.doi10.1039/C8NJ06274A
dc.relation.projectIDinfo:eu-repo/grantAgreement/CONICET-CCT-La Plata/PIP-0651
dc.relation.projectIDinfo:eu-repo/grantAgreement/CONICET-CCT-La Plata/PIP-0034
dc.relation.projectIDinfo:eu-repo/grantAgreement/ANPCyT/PICT 2016-1574
dc.relation.projectIDinfo:eu-repo/grantAgreement/UNLP/11-X473
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2016-75023-C2-1-P
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2015-70371- REDT
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU076U16
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU022G18
dc.identifier.essn1369-9261
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion


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