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dc.contributor.authorSoto Cerrato, Vanessa
dc.contributor.authorManuel Manresa, Pilar .
dc.contributor.authorHernando Santa Cruz, Elsa 
dc.contributor.authorCalabuig Fariñas, Silvia
dc.contributor.authorMartínez Romero, Alicia
dc.contributor.authorFernández Dueñas, Víctor
dc.contributor.authorSahlholm, Kristoffer
dc.contributor.authorKnöpfel, Thomas
dc.contributor.authorGarcía Valverde, María 
dc.contributor.authorRodilla, Ananda M.
dc.contributor.authorJantus Lewintre, Eloisa
dc.contributor.authorFarràs, Rosa
dc.contributor.authorCiruela, Francisco
dc.contributor.authorPérez Tomás, Ricardo
dc.contributor.authorQuesada Pato, Roberto 
dc.date.accessioned2020-07-10T09:36:52Z
dc.date.available2020-07-10T09:36:52Z
dc.date.issued2015-12
dc.identifier.issn0002-7863
dc.identifier.urihttp://hdl.handle.net/10259/5370
dc.description.abstractFacilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation.en
dc.description.sponsorshippanishgovernment and the EU (FIS PI13/00089, FIS PI12/02838,FIS PI12/00956 and RD12/0036/0025), a grant from LaMaratóde TV3 Foundation (20132730), a grant from SEPAR(17/2014), Consejería de Educación de la Junta de Castilla yLeón (Project BU340U13), Ministerio de Economíaycompetitividad/Instituto de Salud Carlos III (SAF2014-55700-P), and ICREA Academia-2010es
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.relation.ispartofJournal of the American Chemical Society. 2015, V. 137, n. 50, p. 15892-15898es
dc.subject.otherQuímica orgánicaes
dc.subject.otherChemistry, Organicen
dc.titleFacilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cellsen
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1021/jacs.5b09970
dc.identifier.doi10.1021/jacs.5b09970
dc.identifier.essn1520-5126
dc.journal.titleJournal of the American Chemical Societyes
dc.volume.number137es
dc.issue.number50es
dc.page.initial15892es
dc.page.final15898es
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion


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