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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/5703

    Título
    Therapeutic strategies involving survivin inhibition in cancer
    Autor
    Martínez García, David
    Manero Rupérez, Noemí
    Quesada Pato, RobertoAutoridad UBU Orcid
    Korrodi Gregório, Luís
    Soto Cerrato, Vanessa
    Publicado en
    Medicinal Research Reviews. 2019, V. 39, n. 3, p. 887-909
    Editorial
    Wiley
    Fecha de publicación
    2019-05
    ISSN
    0198-6325
    DOI
    10.1002/med.21547
    Resumen
    Survivin is a small protein that belongs to the inhibitor of apoptosis protein family. It is abundantly expressed in tumors compared with adult differentiated tissues, being associated with poor prognosis in many human neoplasms. This apoptotic inhibitor has a relevant role in both the promotion of cancer cell survival and in the inhibition of cell death. Consequently, aberrant survivin expression stimulates tumor progression and confers resistance to several therapeutic strategies in a variety of tumors. In fact, efficient survivin downregulation or inhibition results in spontaneous apoptosis or sensitization to chemotherapy and radiotherapy. Therefore, all these features make survivin an attractive therapeutic target to treat cancer. Currently, there are several survivin inhibitors under clinical evaluation, although more specific and efficient survivin inhibitors are being developed. Moreover, novel combination regimens targeting survivin together with other therapeutic approaches are currently being designed and assessed. In this review, recent progress in the therapeutic options targeting survivin for cancer treatment is analyzed. Direct survivin inhibitors and their current development status are explored. Besides, the major signaling pathways implicated in survivin regulation are described and different therapeutic approaches involving survivin indirect inhibition are evaluated. Finally, promising novel inhibitors under preclinical or clinical evaluation as well as challenges of developing survivin inhibitors as a new therapy for cancer treatment are discussed.
    Palabras clave
    anticancer therapy
    apoptosis
    chemoresistance
    inhibitor ofapoptosis proteins
    SMAC mimetics
    survivin inhibitors
    Materia
    Química orgánica
    Chemistry, Organic
    URI
    http://hdl.handle.net/10259/5703
    Versión del editor
    https://doi.org/10.1002/med.21547
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    Nombre:
    Martinez-mrr_2019.pdf
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