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dc.contributor.authorMartínez Lara, Fernando 
dc.contributor.authorSuárez, Anisley 
dc.contributor.authorVelasco Pérez, Noelia 
dc.contributor.authorSuarez Pantiga, Samuel 
dc.contributor.authorSanz Díez, Roberto 
dc.date.accessioned2021-11-04T09:29:09Z
dc.date.available2021-11-04T09:29:09Z
dc.date.issued2021-09
dc.identifier.issn1615-4169
dc.identifier.urihttp://hdl.handle.net/10259/6090
dc.description.abstractPropargylic glycols, 2-alkynyl-1-(indol-3-yl)-1,2-diols, react with thiols undergoing a complex but selective gold-catalyzed transformation that gives rise to α-indol-3-yl α-((Z)-2-thioalkenyl) ketones. The sequence is triggered by the regioselective thiolation of indolyl diols followed by an attack of the sulfur instead of the indole over the activated alkyne. The final compounds are obtained in remarkably high yields and arise from simple starting materials such as indolyl acyloins, ethynyl magnesium bromide and thiols.en
dc.description.sponsorshipMinisterio de Ciencia e Innovación and FEDER (CTQ2016-75023-C2-1-P and PID2020- 115789GB-C21), and Junta de Castilla y León and FEDER (BU291P18 and BU049P20) for financial support. The project leading to these results has received funding from “la Caixa” Foundation, under the Agreement LCF/PR/PR18/51130007> (CAIXA-UBU001). F. M.-L., N. V. and S. S.-P. thank Junta de Castilla y León (Consejería de Educación) and Fondo Social Europeo for predoctoral (F. M.-L. and N. V) and postdoctoral (S. S.-P.) contracts, respectively.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherWileyen
dc.relation.ispartofAdvanced Synthesis & Catalysis. 2021, V. 363en
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectGolden
dc.subjectHomogeneous catalysisen
dc.subjectNitrogen heterocyclesen
dc.subjectRearrangementen
dc.subjectSulfuren
dc.subject.otherQuímica orgánicaes
dc.subject.otherChemistry, Organicen
dc.titleGold-Catalyzed Reactions of 2-Alkynyl-1-indolyl-1,2-diols with Thiols: Stereoselective Synthesis of (Z)-α-Indol-3-yl α-(2-Thioalkenyl) Ketonesen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1002/adsc.202100930
dc.identifier.doi10.1002/adsc.202100930
dc.journal.titleAdvanced Synthesis & Catalysises
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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