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dc.contributor.authorOlmo Alonso, Fabiola
dc.contributor.authorRodríguez Rubio, Andrea
dc.contributor.authorColina Santamaría, Álvaro 
dc.contributor.authorHeras Vidaurre, Aránzazu 
dc.date.accessioned2021-11-08T12:01:45Z
dc.date.available2021-11-08T12:01:45Z
dc.date.issued2021-08
dc.identifier.issn1433-0768
dc.identifier.urihttp://hdl.handle.net/10259/6118
dc.description.abstractUV/Vis absorption spectroelectrochemistry is a very promising analytical technique due to the complementary information that is simultaneously obtained from electrochemistry and spectroscopy. In this work, this technique is used in a parallel configuration to study the oxidation of folic acid in alkaline medium. Herein, UV/Vis absorption spectroelectrochemistry has been used to detect both the oxidation products and the folic acid consumed at the electrode/solution interface, allowing us to develop an analytical protocol to quantify vitamin B9 in pharmaceutical tablets. Linear ranges of three orders of magnitude have been achieved in basic medium (pH = 12.9), obtaining high repeatability and low detection limits. The spectroelectrochemical determination of folic acid in pharmaceutical tablets at alkaline pH values is particularly interesting because of the changes that occur in the optical signal during the electrochemical oxidation of FA, providing results with very good figures of merit and demonstrating the utility and versatility of this hyphenated technique, UV/Vis absorption spectroelectrochemistry.en
dc.description.sponsorshipMinisterio de Economía y Competitividad (Grant CTQ2017-83935-R-AEI/FEDERUE), Junta de Castilla y León (Grant BU297P18), and Ministerio de Ciencia, Innovación y Universidades (Grant RED2018-102412-T). F.O. is grateful for the contract funded by Junta de Castilla y León, the European Social Fund, and the Youth Employment Initiative.
dc.format.mimetypeapplication/pdf
dc.language.isoengen
dc.publisherSpringer
dc.relation.ispartofJournal of Solid State Electrochemistry. 2021en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectVitamin B9en
dc.subjectPharmaceutical drugen
dc.subjectElectrochemistryen
dc.subjectUV/Vis absorption spectroscopyen
dc.subject.otherQuímica analíticaes
dc.subject.otherChemistry, Analyticen
dc.titleUV/Vis absorption spectroelectrochemistry of folic aciden
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1007/s10008-021-05026-5es
dc.identifier.doi10.1007/s10008-021-05026-5
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones
dc.description.projectPublicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE


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