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dc.contributor.authorVulcano, Fabio
dc.contributor.authorKovtun, Alessandro
dc.contributor.authorBettini, Cristian
dc.contributor.authorXia, Zhenyuan
dc.contributor.authorLiscio, Andrea
dc.contributor.authorTerzi, Fabio
dc.contributor.authorHeras, Aránzazu 
dc.contributor.authorColina, Álvaro 
dc.contributor.authorZanfrognini, Barbara
dc.contributor.authorMelucci, Manuela
dc.date.accessioned2021-11-08T12:02:02Z
dc.date.available2021-11-08T12:02:02Z
dc.date.issued2020-04
dc.identifier.issn2053-1583
dc.identifier.urihttp://hdl.handle.net/10259/6119
dc.description.abstractWe describe a nanocomposite material for the electrochemical detection of β-nicotinamide adenine dinucleotide (NADH), a coenzyme involved in redox reactions of all living cells and in the detection of many organic species by electrochemical biosensors. The composite is made of nanosheets of electrochemically exfoliated graphene oxide (EGO) covalently functionalized with dopamine (DP) molecules. The EGODP material finally obtained is rich of 1,2-dihydroxyphenyl moieties and is able to detect NADH at a particular low potential value with higher sensitivity with respect to pristine EGO. To study the effectiveness of 1,2-dihydroxyphenyl moieties in inducing electrocatalytic oxidation of NADH, we combined standard voltammetric techniques with UV–Vis absorption spectroelectrochemistry, which allowed us to measure the variations in composition occurring at the electrode|solution interface, i.e. to measure the consumption rate of NADH. Spectroelectrochemical tests performed by polarising the electrode at a fixed potential value were finally used to compare the performance of EGODP with both EGO and EGO-DP blend (MIX) for the detection of NADH. The covalently functionalized EGO (EGODP) shows sensitivity to NADH up to 300 M−1, around 180 % and 140 % better than either pristine EGO or MIX, respectively.en
dc.description.sponsorshipSpanish Ministerio de Economía y Competitividad (Grants CTQ2017-83935-R-AEI/FEDERUE), Ministerio de Ciencia, Innovación y Universidades (RED2018-102412-T) and Junta de Castilla y León (Grant BU297P18).
dc.format.mimetypeapplication/pdf
dc.language.isospaes
dc.publisherIOP Publishing
dc.relation.ispartof2D Materials. 2020, V. 7, n. 2, 024007
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/*
dc.subjectgraphene oxideen
dc.subjectspectroelectrochemistryen
dc.subjectNADH
dc.subjectchemical functionalizationen
dc.subject1,2-dihydroxyphenyl moietiesen
dc.subject.otherQuímica analíticaes
dc.subject.otherChemistry, Analyticen
dc.titleDopamine-functionalized graphene oxide as a high-performance material for biosensingen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1088/2053-1583/ab734f
dc.identifier.doi10.1088/2053-1583/ab734f
dc.identifier.essn2053-1583
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones


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