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dc.contributor.authorHernández Muñoz, Sheila 
dc.contributor.authorPerales Rondon, Juan Víctor 
dc.contributor.authorArnaiz González, Álvar 
dc.contributor.authorPérez Estébanez, Martín
dc.contributor.authorGomez, Elvira
dc.contributor.authorColina, Álvaro 
dc.contributor.authorHeras, Aránzazu 
dc.date.accessioned2021-11-09T10:39:47Z
dc.date.available2021-11-09T10:39:47Z
dc.date.issued2020-12
dc.identifier.issn1572-6657
dc.identifier.urihttp://hdl.handle.net/10259/6130
dc.description.abstractTime resolved Raman spectroelectrochemistry is a powerful technique to prepare useful Surface Enhanced Raman Scattering (SERS) substrates suitable for quantitative analysis. Moreover, following the evolution of the Raman signal with the applied potential the selection of the best conditions for the analysis is quite simple. In this work, gold SERS substrates are prepared on screen-printed electrodes for the determination of nicotinamide, vitamin B3, in a multivitamin complex. The formation of the substrate has been monitored using UV/Vis absorption spectroelectrochemistry and scanning electron microscopy, which confirmed the generation of gold nanoparticles on the electrode surface. This new method has demonstrated to be suitable for the direct quantification of simple test samples using small sample volumes (50 μL). However, it failed when a complex sample, containing several interfering species, was analysed. A high interference on the preparation of the SERS substrate is observed during the analysis of a multivitamin complex. Despite that, nicotinamide was selectively determined in a multivitamin complex using the method of the standard addition, obtaining remarkable figures of merit (R2 = 0.99, %RSD < 9%).en
dc.description.sponsorshipMinisterio de Economía, y Competitividad (Grant CTQ2017-83935-R-AEI/FEDERUE), Junta de Castilla y León (Grant BU297P18) and Ministerio de Ciencia, Innovación y Universidades (Grant RED2018-102412-T). J.V.P-R. thanks Junta de Castilla y León for his postdoctoral fellowship (Grant BU033-U16)
dc.format.mimetypeapplication/pdf
dc.language.isospaes
dc.publisherElsevier
dc.relation.ispartofJournal of Electroanalytical Chemistry. 2020, V. 879, 114743
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSpectroelectrochemistryen
dc.subjectVitamin B3en
dc.subjectEC-SERSen
dc.subjectRaman spectroscopyen
dc.subjectStandard addition methoden
dc.subject.otherQuímica analíticaes
dc.subject.otherChemistry, Analyticen
dc.titleDetermination of nicotinamide in a multivitamin complex by electrochemical-surface enhanced Raman spectroscopyen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses
dc.relation.publisherversionhttps://doi.org/10.1016/j.jelechem.2020.114743es
dc.identifier.doi10.1016/j.jelechem.2020.114743
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones


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