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dc.contributor.authorMuñoz Moreno, Raquel
dc.contributor.authorMartínez Romero, Carles
dc.contributor.authorBlanco Melo, Daniel
dc.contributor.authorForst, Christian V.
dc.contributor.authorNachbagauer, Raffael
dc.contributor.authorBenitez, Asiel Arturo
dc.contributor.authorMena, Ignacio
dc.contributor.authorAslam, Sadaf
dc.contributor.authorBalasubramaniam, Vinod
dc.contributor.authorLee, Ilseob
dc.contributor.authorPanis, Maryline
dc.contributor.authorAyllón Barasoain, Juan 
dc.contributor.authorSachs, David
dc.contributor.authorPark, Man-Seong
dc.contributor.authorKrammer, Florian
dc.contributor.authortenOever, Benjamin R.
dc.contributor.authorGarcía Sastre, Adolfo
dc.date.accessioned2023-11-10T13:46:28Z
dc.date.available2023-11-10T13:46:28Z
dc.date.issued2019
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/10259/7994
dc.description.abstractInfluenza A viruses (IAVs) have a remarkable tropism in their ability to circulate in both mammalian and avian species. The IAV NS1 protein is a multifunctional virulence factor that inhibits the type I interferon host response through a myriad of mechanisms. How NS1 has evolved to enable this remarkable property across species and its specific impact in the overall replication, pathogenicity, and host preference remain unknown. Here we analyze the NS1 evolutionary landscape and host tropism using a barcoded library of recombinant IAVs. Results show a surprisingly great variety of NS1 phenotypes according to their ability to replicate in different hosts. The IAV NS1 genes appear to have taken diverse and random evolutionary pathways within their multiple phylogenetic lineages. In summary, the high evolutionary plasticity of this viral protein underscores the ability of IAVs to adapt to multiple hosts and aids in our understanding of its global prevalence.en
dc.description.sponsorshipThis research work was supported partially by CRIP (Center for Research on Influenza Pathogenesis), an NIH-NIAID-funded Center of Excellence for Influenza Research and Surveillance (CEIRS) (contract HHSN272201400008C), and by NIH-NIAID (grants U19AI117873 and U19AI135972). This research was also supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF), funded by the Ministry of Science and ICT of the Republic of Korea (NRF-2018M3A9H4056537 to M.-S.P., PI).es
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherCell Presses
dc.relation.ispartofCell Reports. 2019, V. 29, n. 12, p. 3997-4009.e5es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectInfluenza virusen
dc.subjectOrthomyxovirusen
dc.subjectNS1 evolutionen
dc.subjectIFN responseen
dc.subjectInnate immunityen
dc.subjectBarcoded libraryen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.subject.otherSaludes
dc.subject.otherHealthen
dc.subject.otherMicrobiologíaes
dc.subject.otherMicrobiologyen
dc.subject.otherGenéticaes
dc.subject.otherGeneticsen
dc.subject.otherEnfermedades infecciosases
dc.subject.otherCommunicable diseasesen
dc.titleViral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Virusesen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1016/j.celrep.2019.11.070es
dc.identifier.doi10.1016/j.celrep.2019.11.070
dc.journal.titleCell Reportses
dc.volume.number29es
dc.issue.number12es
dc.page.initial3997es
dc.page.final4009.e5es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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