Universidad de Burgos Repositorio Repositorio
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/4257

Ver estadísticas de uso
Título : Determination of dichlobenil and its major metabolite (BAM) in onions by PTV–GC–MS using PARAFAC2 and experimental design methodology
Autor : Herrero Gutiérrez, Ana
Reguera Alonso, Celia
Ortiz Fernández, Mª Cruz
Sarabia Peinador, Luis Antonio
Publicado en: Chemometrics and intelligent laboratory systems. 2014, V. 133, p. 92–108
Editorial : Elsevier
Fecha de publicación : abr-2014
ISSN : 0169-7439
DOI: 10.1016/j.chemolab.2013.12.001
Resumen : The optimization of a GC–MS analytical procedure which includes derivatization, Quick Easy Cheap Effective Rugged and Safe (QuEChERS) and programmed temperature vaporization (PTV) using design of experiments is performed to determine 2,6-dichlorobenzonitrile (dichlobenil) and 2,6-dichlorobenzamide (BAM) in onions, using 3,5-dichlorobenzonitrile and 2,4-dichlorobenzamide as internal standards. The use of a central composite design and two D-optimal designs, together with the desirability function, makes it possible to significantly reduce the economic, time and environmental cost of the study. The usefulness of PARAFAC2 for solving problems as the interference of unexpected derivatization artifacts unavoidably linked to some derivatization agents, or the presence of coeluents from the complex matrix, which share m/z ratios with the target compounds, is shown. The limits of decision (CCα) of the optimized procedure, 5.00 μg kg− 1 for dichlobenil and 1.55 μg kg− 1 for BAM (α = 0.05), are below the maximum residue limit (MRL) established by the EU for dichlobenil (20 μg kg− 1) in this commodity.
Palabras clave: PTV–GC–MS
D-optimal design
Parallel factor analysis
Desirability function
Dichlobenil
SANCO/12495/2001
Materia: Química analítica
Chemistry, Analytic
Licencia: http://creativecommons.org/licenses/by-nc-nd/4.0/
URI : http://hdl.handle.net/10259/4257
Versión del editor: http://dx.doi.org/10.1016/j.chemolab.2013.12.001
Aparece en las colecciones: Artículos Q&C

Ficheros en este ítem:

Fichero Descripción Tamaño Formato
Herrero-CILS_2014.pdf985,04 kBAdobe PDFVisualizar/Abrir

Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons
Creative Commons

Los ítems del Repositorio Institucional de la Universidad de Burgos están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2008 MIT and Hewlett-Packard - Sobre DSpace