A new route to regioselectively dialkoxy-functionalized benzo[b]furan derivatives has been developed from 3-halo-2-iodoanisoles
bearing an additional methoxy group, which have been accessed through an ortho-zincation/iodination reaction. Two palladiumcatalyzed
processes, namely a Sonogashira coupling followed by a tandem hydroxylation/cyclization sequence, give rise to new and
interesting dimethoxy-substituted benzo[b]furans.
