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dc.contributor.authorMorro, Ana
dc.contributor.authorAbrusci, Concepción
dc.contributor.authorPablos, Jesús Luis
dc.contributor.authorMarín, Irma
dc.contributor.authorGarcía García, Félix Clemente 
dc.contributor.authorGarcía Pérez, José Miguel 
dc.date.accessioned2017-04-28T09:26:17Z
dc.date.available2019-06-01T02:45:06Z
dc.date.issued2017-06
dc.identifier.urihttp://hdl.handle.net/10259/4436
dc.description.abstractMicrobial colonisation of synthetic materials is a great concern in many fields, e.g., in implant surgery and medical devices; therefore biocompatible hydrophilic organic materials with inherent antimicrobial properties are of current research interest. In this work, we describe the preparation of antibacterial and biocompatible polymeric film based on N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl acrylate (HEA), using ethyleneglycol dimethacrylate (EGDMA), and synthetic acrylic monomer containing sulfadiazine chemically anchored. The synthesised polyvinylpyrrolidone (PVP)-based films were characterized by different techniques (1H and 13C NMR, ATR-FTIR, SEM, and TGA). In this study, the biophysical responses of bacteria and L929 cells towards the prepared materials as model device surfaces were evaluated. The membrane that contains the anchored sulfadiazine moiety showed excellent antibacterial activity against Escherichia coli as well as good biocompatibility. Based on the experimental results, this material is a good candidate for medical applications as a biomaterial.en
dc.description.sponsorshipSpanish Ministerio de Economía y Competitividad-Feder (MAT2014-54137-R and MAT2012-31709) and by the Consejería de Educación – Junta de Castilla y León – Feder (BU061U16)en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieren
dc.relation.ispartofEuropean Polymer Journal. 2017, V. 91, p. 274–282en
dc.subjectPVPen
dc.subjectSulfadiazineen
dc.subjectAntibacterial polymeren
dc.subjectBiocompatibleen
dc.titleInherent antibacterial activity and in vitro biocompatibility of hydrophilic polymer film containing chemically anchored sulfadiazine moietiesen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1016/j.eurpolymj.2017.04.012
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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