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dc.contributor.authorHernando Santa Cruz, Elsa 
dc.contributor.authorSoto Cerrato, Vanessa .
dc.contributor.authorCortés Arroyo, Susana .
dc.contributor.authorPérez Tomás, Ricardo .
dc.contributor.authorQuesada Pato, Roberto 
dc.date.accessioned2018-08-23T08:29:20Z
dc.date.available2018-08-23T08:29:20Z
dc.date.issued2014-03
dc.identifier.issn1477-0520
dc.identifier.urihttp://hdl.handle.net/10259/4876
dc.description.abstractTen synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, have been synthesized. These compounds proved to be highly efficient transmembrane anion transporters in model liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or the alkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity of these compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50 values in the low micromolar range as well as modify the intracellular pH, inducing the basification of acidic organelles.en
dc.description.sponsorshipConsejería de Educación de la Junta de Castilla y León (Project BU340U13) and Fundació la Maratón de TV3.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofOrganic & Biomolecular Chemistry. 2014, V. 12, n. 11, p. 1771-1778en
dc.subject.otherQuímica orgánicaes
dc.subject.otherChemistry, Organicen
dc.titleTransmembrane anion transport and cytotoxicity of synthetic tambjamine analogsen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1039/c3ob42341g
dc.identifier.doi10.1039/c3ob42341g
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU340U13
dc.relation.projectIDinfo:eu-repo/grantAgreement/TV3Foundation/20132732
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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