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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/4876

    Título
    Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs
    Autor
    Hernando Santa Cruz, ElsaUBU authority Orcid
    Soto Cerrato, Vanessa
    Cortés Arroyo, Susana .
    Pérez Tomás, Ricardo
    Quesada Pato, RobertoUBU authority Orcid
    Publicado en
    Organic & Biomolecular Chemistry. 2014, V. 12, n. 11, p. 1771-1778
    Editorial
    Royal Society of Chemistry
    Fecha de publicación
    2014-03
    ISSN
    1477-0520
    DOI
    10.1039/c3ob42341g
    Abstract
    Ten synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, have been synthesized. These compounds proved to be highly efficient transmembrane anion transporters in model liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or the alkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity of these compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50 values in the low micromolar range as well as modify the intracellular pH, inducing the basification of acidic organelles.
    Materia
    Química orgánica
    Chemistry, Organic
    URI
    http://hdl.handle.net/10259/4876
    Versión del editor
    https://doi.org/10.1039/c3ob42341g
    Collections
    • Artículos BIOORG
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