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dc.contributor.authorGuembe García, Marta
dc.contributor.authorVallejos Calzada, Saúl 
dc.contributor.authorCarreira Barral, Israel
dc.contributor.authorIbeas Cortes, Saturnino 
dc.contributor.authorGarcía García, Félix Clemente 
dc.contributor.authorSantaolalla García, Victoria
dc.contributor.authorMoradillo Renuncio, Natalia
dc.contributor.authorGarcía Pérez, José Miguel 
dc.date.accessioned2020-07-27T10:30:20Z
dc.date.available2020-07-27T10:30:20Z
dc.date.issued2020-09
dc.identifier.issn1381-5148
dc.identifier.urihttp://hdl.handle.net/10259/5396
dc.description.abstractWe have developed a new sensory material for the rapid and inexpensive determination of Zn(II), and we have carried out a proof of concept for the determination of Zn(II) in biological samples. The interaction with Zn(II) generates an OFF-ON fluorescence process on the material, which can be recorded both with a fluorimeter and with a smartphone by analyzing the RGB components of the taken photographs. This sensory material is prepared with 99.75% of commercially available monomers and contains 0.25% of a sensory monomer based on a quinoline structure. The sensory motifs are chemically anchored to the polymeric structure, and, accordingly, no migration of organic substances from the material occurs during the sensing process. Our method has been tested with freshly prepared Zn(II) aqueous solutions, but also with biological samples from exudates of chronic wounds. The proposed methodology provides limits of detection (LOD) of 13 and 27 ppb when employing a water-soluble polymer (WsP) and a hydrophilic polymeric film (HP), respectively, using emission spectroscopy. The measurements have been contrasted with ICP-MS as the reference method, obtaining reliable data. This study is the starting point toward a larger investigation with patients, which will address the challenge of establishing a direct relationship between the concentration of zinc(II), other cations and also of amino acids, with the protease activity and, finally, with the state/evolution of chronic wounds. In this context, the proposed sensory material and others we are now working with will act as a simple and cheap method for this purpose.en
dc.description.sponsorshipFEDER (Fondo Europeo de Desarrollo Regional), and both the Spanish Ministerio de Economía, Industria y Competitividad (MAT2017-84501-R) and the Consejería de Educación—Junta de Castilla y León (BU061U16)es
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofReactive and Functional Polymers. 2020, V. 154, 104685es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSmart materialsen
dc.subjectSensory polymersen
dc.subjectZinc(II) detectionen
dc.subjectBiological samplesen
dc.subjectChronic woundsen
dc.subject.otherQuímica orgánicaes
dc.subject.otherChemistry, Organicen
dc.titleZn(II) detection in biological samples with a smart sensory polymeren
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccess
dc.relation.publisherversionhttps://doi.org/10.1016/j.reactfunctpolym.2020.104685
dc.identifier.doi10.1016/j.reactfunctpolym.2020.104685
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2017-84501-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU061U16
dc.journal.titleReactive and Functional Polymersen
dc.volume.number154es
dc.page.initial104685es
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion


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