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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/5588

    Título
    Assessment of Physico-Chemical and Toxicological Properties of Commercial 2D Boron Nitride Nanopowder and Nanoplatelets
    Autor
    Domi, BrixhildaAutoridad UBU Orcid
    Bhorkar, Kapil
    Rumbo Lorenzo, CarlosAutoridad UBU Orcid
    Sygellou, Labrini
    Yannopoulos, Spyros N.
    Barros García, RocíoAutoridad UBU Orcid
    Quesada Pato, RobertoAutoridad UBU Orcid
    Tamayo Ramos, Juan AntonioAutoridad UBU Orcid
    Publicado en
    International Journal of Molecular Sciences. 2021, V. 22, n. 2, 567
    Editorial
    MDPI
    Fecha de publicación
    2021-01
    DOI
    10.3390/ijms22020567
    Resumen
    Boron nitride (BN) nanomaterials have been increasingly explored for potential applications in chemistry and biology fields (e.g., biomedical, pharmaceutical, and energy industries) due to their unique physico-chemical properties. However, their safe utilization requires a profound knowledge on their potential toxicological and environmental impact. To date, BN nanoparticles have been considered to have a high biocompatibility degree, but in some cases, contradictory results on their potential toxicity have been reported. Therefore, in the present study, we assessed two commercial 2D BN samples, namely BN-nanopowder (BN-PW) and BN-nanoplatelet (BN-PL), with the objective to identify whether distinct physico-chemical features may have an influence on the biological responses of exposed cellular models. Morphological, structural, and composition analyses showed that the most remarkable difference between both commercial samples was the diameter of their disk-like shape, which was of 200–300 nm for BN-PL and 100–150 nm for BN-PW. Their potential toxicity was investigated using adenocarcinomic human alveolar basal epithelial cells (A549 cells) and the unicellular fungus Saccharomycescerevisiae, as human and environmental eukaryotic models respectively, employing in vitro assays. In both cases, cellular viability assays and reactive oxygen species (ROS) determinations where performed. The impact of the selected nanomaterials in the viability of both unicellular models was very low, with only a slight reduction of S. cerevisiae colony forming units being observed after a long exposure period (24 h) to high concentrations (800 mg/L) of both nanomaterials. Similarly, BN-PW and BN-PL showed a low capacity to induce the formation of reactive oxygen species in the studied conditions. Even at the highest concentration and exposure times, no major cytotoxicity indicators were observed in human cells and yeast. The results obtained in the present study provide novel insights into the safety of 2D BN nanomaterials, indicating no significant differences in the toxicological potential of similar commercial products with a distinct lateral size, which showed to be safe products in the concentrations and exposure conditions tested.
    Palabras clave
    2D boron nitride
    Eukaryotic model
    Nanotoxicity
    Cell viability
    Oxidative stress
    Materia
    Materia-Composición
    Matter-Constitution
    Materiales
    Materials
    URI
    http://hdl.handle.net/10259/5588
    Versión del editor
    https://doi.org/10.3390/ijms22020567
    Aparece en las colecciones
    • Artículos ICCRAM
    Atribución 4.0 Internacional
    Documento(s) sujeto(s) a una licencia Creative Commons Atribución 4.0 Internacional
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    Nombre:
    Domi-ijms_2021.pdf
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    1.239Mb
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