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dc.contributor.authorRumbo Lorenzo, Carlos 
dc.contributor.authorBianchin, Alvise
dc.contributor.authorLocci, Antonio Mario
dc.contributor.authorBarros García, Rocío 
dc.contributor.authorMartel Martín, Sonia 
dc.contributor.authorTamayo Ramos, Juan Antonio 
dc.date.accessioned2022-02-08T13:40:39Z
dc.date.available2022-02-08T13:40:39Z
dc.date.issued2022-01
dc.identifier.urihttp://hdl.handle.net/10259/6409
dc.description.abstractThe development of new candidate alloys with outstanding characteristics for their use in the aeronautical field is one of the main priorities for the sector. In this context, nanocrystaline (nc) alloys are considered relevant materials due to their special features, such as their exceptional physical and mechanical properties. However, another important point that needs to be considered with newly developed alloys is the potential toxicological impact that these materials may have in humans and other living organisms. The aim of this work was to perform a preliminary toxicological evaluation of three nc metal alloys (WCu, WAl and TiAl) in powder form produced by mechanical alloying, applying different in vitro assays, including a mix of W-Cu powders with standard grain size in the experiments to stablish comparisons. The effects of the direct exposure to powder suspensions and/or to their derived leachates were analysed in three model organisms representative of human and environmental exposures (the adenocarcinomic human alveolar basal epithelial cell line A549, the yeast Saccharomyces cerevisiae and the Gram negative bacterium Vibrio fischeri). Altogether, the results obtained provide new insights about the potential harmful effects of the selected nc alloys, showing that, from a toxicological perspective, nc TiAl is the safest candidate in the model organisms and conditions tested.en
dc.description.sponsorshipEU Horizon 2020 projects ICARUS (H2020-FETOPEN-2014-2015-RIA, grant agreement N° 713514) and ICARUS-INAS (FETOPEN-03-2018-2019-2020, Grant agreement N° 946174).en
dc.language.isoenges
dc.publisherNatureen
dc.relation.ispartofScientific Reports. 2022, V. 12, 1523en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCell biologyen
dc.subjectEnvironmental impacten
dc.subjectMicrobiologyen
dc.subject.otherBiología moleculares
dc.subject.otherMolecular biologyen
dc.subject.otherMicrobiologíaes
dc.subject.otherMicrobiologyen
dc.subject.otherQuímica físicaes
dc.subject.otherChemistry, Physical and theoreticalen
dc.titleToxicological assessment of nanocrystalline metal alloys with potential applications in the aeronautical fielden
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-022-05406-5es
dc.identifier.doi10.1038/s41598-022-05406-5
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/713514/EU/ICARUS (Innovative Coarsening-resistant Alloys with enhanced Radiation tolerance and Ultra-fine -grained Structure for aerospace application)en
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/946174/EU/ICARUS-INAS (Intregrated Nanostructures Assessment-Service for the biological impact analysis of nanostructures)en
dc.identifier.essn2045-2322
dc.journal.titleScientific Reportsen
dc.volume.number12es
dc.issue.number1es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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