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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/6409

    Título
    Toxicological assessment of nanocrystalline metal alloys with potential applications in the aeronautical field
    Autor
    Rumbo Lorenzo, CarlosUBU authority
    Bianchin, Alvise
    Locci, Antonio Mario
    Barros García, Rocío
    Martel Martín, Sonia
    Tamayo Ramos, Juan AntonioUBU authority
    Publicado en
    Scientific Reports. 2022, V. 12, 1523
    Editorial
    Nature
    Fecha de publicación
    2022-01
    DOI
    10.1038/s41598-022-05406-5
    Abstract
    The development of new candidate alloys with outstanding characteristics for their use in the aeronautical field is one of the main priorities for the sector. In this context, nanocrystaline (nc) alloys are considered relevant materials due to their special features, such as their exceptional physical and mechanical properties. However, another important point that needs to be considered with newly developed alloys is the potential toxicological impact that these materials may have in humans and other living organisms. The aim of this work was to perform a preliminary toxicological evaluation of three nc metal alloys (WCu, WAl and TiAl) in powder form produced by mechanical alloying, applying different in vitro assays, including a mix of W-Cu powders with standard grain size in the experiments to stablish comparisons. The effects of the direct exposure to powder suspensions and/or to their derived leachates were analysed in three model organisms representative of human and environmental exposures (the adenocarcinomic human alveolar basal epithelial cell line A549, the yeast Saccharomyces cerevisiae and the Gram negative bacterium Vibrio fischeri). Altogether, the results obtained provide new insights about the potential harmful effects of the selected nc alloys, showing that, from a toxicological perspective, nc TiAl is the safest candidate in the model organisms and conditions tested.
    Palabras clave
    Cell biology
    Environmental impact
    Microbiology
    Materia
    Biología molecular
    Molecular biology
    Microbiología
    Microbiology
    Química física
    Chemistry, Physical and theoretical
    URI
    http://hdl.handle.net/10259/6409
    Versión del editor
    https://doi.org/10.1038/s41598-022-05406-5
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