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dc.contributor.authorFernández-Lázaro, Diego
dc.contributor.authorGarcía Hernández, Juan Luis
dc.contributor.authorLumbreras, Eva
dc.contributor.authorMielgo Ayuso, Juan 
dc.contributor.authorSeco-Calvo, Jesús
dc.date.accessioned2023-03-22T08:25:38Z
dc.date.available2023-03-22T08:25:38Z
dc.date.issued2022-10
dc.identifier.urihttp://hdl.handle.net/10259/7579
dc.description.abstractSarcopenia (Sp) is the loss of skeletal muscle mass associated with aging that results in an involution of muscle function and strength. Vitamin D deficiency is a common health problem worldwide, especially among the elderly, and hypovitaminosis D leads to musculoskeletal disorders. The aim of this study was to evaluate the impact and presence of a possible linkage between Single Nucleotide Polymorphisms (SNPs) CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs2228570), serum 25-OH/D concentrations and the link with the degree of sarcopenia in 19 institutionalized elderly men not supplemented with vitamin D. Levels of 25-OH vitamin D were quantified with a commercial enzyme-linked immunosorbent assay kit and 3 SNPs were genotyped with KASPar assays. Significant differences in 25-OH/D concentration were determined between the bi-allelic combinations of rs228679 and rs228570. We detected statistically significant weak positive correlations between the AA (rs10741657 and rs228570) and TT (rs228679) and alleles and 25-OH/D and the probability of having higher 25-OH/D concentrations was 2- to 3-fold higher. However, the GG alleles of the 3 SNPs showed that the probability of having optimal 25-0H/D concentrations decreases by 32% for rs10741657, 38% for rs228679, and 74% for rs228570, showing a strong negative correlation between the degree of sarcopenia and 25-OH/D levels. Allelic variations in CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs10741657) affect vitamin D levels and decisively influence the degree of sarcopenia in institutionalized elderly people.en
dc.description.sponsorshipThis research has been funded by the Chair of Knowledge and Innovation “Caja Rural de Soria” University of Valladolid Campus de Soria, Soria (Spain) in the call for funding research projects with project number SO-1-2020. D.F.-L. and J.M.-A. were members of the research team.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherMDPIen
dc.relation.ispartofInternational Journal of Molecular Sciences. 2022, V. 23, n. 19, 11846en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectElderlyen
dc.subjectAgingen
dc.subjectSarcopeniaen
dc.subject25-OH vitamin Den
dc.subjectDeficiencyen
dc.subjectGeneticsen
dc.subjectCYP2R1en
dc.subjectGCen
dc.subjectVDRen
dc.subject.otherFisiologíaes
dc.subject.otherPhysiologyen
dc.title25-Hydroxyvitamin D Serum Levels Linked to Single Nucleotide Polymorphisms (SNPs) (rs2228570, rs2282679, rs10741657) in Skeletal Muscle Aging in Institutionalized Elderly Men Not Supplemented with Vitamin Den
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.3390/ijms231911846es
dc.identifier.doi10.3390/ijms231911846
dc.relation.projectIDinfo:eu-repo/grantAgreement/UVA//SO-1-2020/ES/es
dc.identifier.essn1422-0067
dc.journal.titleInternational Journal of Molecular Sciencesen
dc.volume.number23es
dc.issue.number19es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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