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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/4282

    Título
    Selectivity of a thiosemicarbazonatocopper(II) complex towards duplex RNA. Relevant noncovalent interactions both in solid state and solution
    Autor
    Gil García, Rubénuntranslated
    Ugalde, Maríauntranslated
    Busto Vázquez, Nataliauntranslated
    Lozano Ordóñez, Héctor J.
    Leal Villalba, José Maríauntranslated
    Pérez, Begoñauntranslated
    Madariaga, Gotzon .
    Insausti, Maite
    Lezama, Luis .
    Sanz Díez, Robertountranslated
    Gómez Sainz, Lidia M.untranslated
    García Ruiz, Begoñauntranslated
    García Tojal, Javieruntranslated
    Publicado en
    Dalton transactions, 2016, n. 45, p. 45, 18704-18718
    Editorial
    Royal Society of Chemistry
    Fecha de publicación
    2016-12
    ISSN
    1477-9226
    Zusammenfassung
    Thiosemicarbazones and their metal derivatives have long been screened as antitumor agents, and their interactions with DNA have been analysed. Herein, we describe the synthesis and characterization of compounds containing [CuL]+ entities (HL = pyridine-2-carbaldehyde thiosemicarbazone) and adenine, cytosine or 9-methylguanine, and some of their corresponding nucleotides. For the first time, crystal structures of adenine- and 9-methylguanine-containing thiosemicarbazone complexes are reported. To the best of our knowledge, the first study on the affinity thiosemicarbazone–RNA is also provided here. Experimental and computational studies have shown that [CuL(OH2)]+ entities at low concentration intercalate into dsRNA poly(rA)·poly(rU) through strong hydrogen bonds involving uracil residues and π–π stacking interactions. In fact, noncovalent interactions are present both in the solid state and in solution. This behaviour diverges from that observed with DNA duplexes and creates an optimistic outlook in achieving selective binding to RNA for subsequent possible medical applications.
    URI
    http://hdl.handle.net/10259/4282
    Versión del editor
    http://dx.doi.org/10.1039/C6DT02907H
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    Nombre:
    Gil-DT_2016.pdf
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