Show simple item record

dc.contributor.authorPino García, Raquel del 
dc.contributor.authorGerardi, Gisela 
dc.contributor.authorRivero Pérez, Maria Dolores 
dc.contributor.authorGonzález San José, Mª Luisa 
dc.contributor.authorGarcía Lomillo, Javier 
dc.contributor.authorMuñiz Rodríguez, Pilar 
dc.date.accessioned2017-01-12T11:22:26Z
dc.date.available2017-04-01T02:45:06Z
dc.date.issued2016-04
dc.identifier.issn1756-4646
dc.identifier.urihttp://hdl.handle.net/10259/4297
dc.description.abstractDietary antioxidants such as phenolic phytochemicals may prevent/improve endothelial function impairment observed in cardiovascular diseases. This study investigates the specific protective effects of a vegetal seasoning obtained from seedless wine pomace against hyperglycaemia-induced oxidative damage and dysfunction in human umbilical vein endothelial cells EA.hy926. Non-cytotoxic doses of the bioactive compounds obtained following in vitro digestion of the seasoning were used as treatments. Digested compounds, especially colonic bacterial metabolites, restored a more balanced redox environment, prevented lipid peroxidation and cell membrane damage, ameliorated protein oxidation, and improved the balance between endothelial reactive oxygen species and nitric oxide production in hyperglycaemic cells. Reduction of angiotensin I-converting enzyme activity and gene modulation of superoxide dismutase, haem oxygenase-1, β-nicotinamide adenine dinucleotide phosphate oxidase-4, and endothelial nitric oxide synthase are proposed as the mechanisms underlying this protection.These results support the potential benefits of functional wine pomace seasonings in vascular complications associated with oxidative stress.en
dc.description.sponsorshipAutonomous Government of Castilla y León (Research project BU282U13). The PhD grants of RDPG and JGL (FPU grants AP2010-1933 and FPU12/05494) are funded by the Ministry of Education, Culture and Sports, Spain.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieren
dc.relation.ispartofJournal of Functional Foods. 2016, V. 22, p. 1-612en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectColonic metabolitesen
dc.subjectDietary antioxidantsen
dc.subjectEndothelial functionen
dc.subjectHyperglycaemiaen
dc.subjectRedox signallingen
dc.subjectWine pomaceen
dc.titleWine pomace seasoning attenuates hyperglycaemia-induced endothelial dysfunction and oxidative damage in endothelial cellsen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.jff.2016.02.001
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record