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dc.contributor.authorVallejos Calzada, Saúl 
dc.contributor.authorHernando Santa Cruz, Elsa 
dc.contributor.authorTrigo López, Miriam 
dc.contributor.authorGarcía García, Félix Clemente 
dc.contributor.authorGarcía Valverde, María 
dc.contributor.authorIturbe, David .
dc.contributor.authorCabero, María Jesús .
dc.contributor.authorQuesada Pato, Roberto 
dc.contributor.authorGarcía Pérez, José Miguel 
dc.date.accessioned2018-06-19T08:23:24Z
dc.date.available2019-06-14T02:45:07Z
dc.date.issued2018-06
dc.identifier.issn2050-750X
dc.identifier.urihttp://hdl.handle.net/10259/4815
dc.description.abstractWe have developed a new extremely hydrophilic polymeric film suitable for the detection and quantification of chloride in human sweat directly on the skin. The film, or membrane, has chemically anchored 6-methoxyquinoline groups as chloride responsive fluorescent motifs. We have prepared the sensory material from a standard vinyl copolymer, by a convenient and easy solid-phase reaction. The sensory material has a water swelling percentage of 700%, facilitating an immediate detection of chloride, is reusable for at least 6 cycles and can be handled without care by unskilled persons. The initially high fluorescence of the material decreases in the presence of chloride, allowing the quantification of chloride concentration by using the colour definition of a digital picture or a fluorimeter. The suitability of the material to perform quantitative chloride analysis of human sweat by putting it in contact with the skin offers promise for its application in the sweat test used for the diagnosis of cystic fibrosis (CF).en
dc.description.sponsorshipFEDER and both the Spanish Ministerio de Economía y Competitividad (MAT2014-54137-R and MAT2017-84501-R) and the Consejería de Educación – Junta de Castilla y León (BU092U16 and BU061U16)en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofJournal of Materials Chemistry B. 2016, V. 6, n. 22, p. 3735-3741en
dc.titlePolymeric chemosensor for the detection and quantification of chloride in human sweat. Application to the diagnosis of cystic fibrosisen
dc.typeArtículoes
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1039/c8tb00682b
dc.identifier.doi10.1039/c8tb00682b
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2014-54137-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2017-84501-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU092U16
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU061U16
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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