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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/4815

    Título
    Polymeric chemosensor for the detection and quantification of chloride in human sweat. Application to the diagnosis of cystic fibrosis
    Autor
    Vallejos Calzada, SaúlUBU authority Orcid
    Hernando Santa Cruz, ElsaUBU authority Orcid
    Trigo López, MiriamUBU authority Orcid
    García García, Félix ClementeUBU authority Orcid
    García Valverde, MaríaUBU authority Orcid
    Iturbe, David .
    Cabero, María Jesús .
    Quesada Pato, RobertoUBU authority Orcid
    García Pérez, José MiguelUBU authority Orcid
    Publicado en
    Journal of Materials Chemistry B. 2016, V. 6, n. 22, p. 3735-3741
    Editorial
    Royal Society of Chemistry
    Fecha de publicación
    2018-06
    ISSN
    2050-750X
    DOI
    10.1039/c8tb00682b
    Abstract
    We have developed a new extremely hydrophilic polymeric film suitable for the detection and quantification of chloride in human sweat directly on the skin. The film, or membrane, has chemically anchored 6-methoxyquinoline groups as chloride responsive fluorescent motifs. We have prepared the sensory material from a standard vinyl copolymer, by a convenient and easy solid-phase reaction. The sensory material has a water swelling percentage of 700%, facilitating an immediate detection of chloride, is reusable for at least 6 cycles and can be handled without care by unskilled persons. The initially high fluorescence of the material decreases in the presence of chloride, allowing the quantification of chloride concentration by using the colour definition of a digital picture or a fluorimeter. The suitability of the material to perform quantitative chloride analysis of human sweat by putting it in contact with the skin offers promise for its application in the sweat test used for the diagnosis of cystic fibrosis (CF).
    Materia
    Chemistry, Organic
    Química orgánica
    URI
    http://hdl.handle.net/10259/4815
    Versión del editor
    https://doi.org/10.1039/c8tb00682b
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    • Artículos POLYMERS
    • Artículos BIOORG
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    Vallejos-JMCB_2018.pdf
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