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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/4882

    Título
    Fishing for G-Quadruplexes in solution with a perylene diimide derivative labeled with biotins
    Autor
    Busto Vázquez, NataliaUBU authority Orcid
    Calvo Gredilla, PatriciaUBU authority
    Santolaya, Javier
    Leal Villalba, José MaríaUBU authority Orcid
    Guédin, Aurore .
    Barone, Giampaolo
    Torroba Pérez, TomásUBU authority Orcid
    Mergny, Jean-Louis
    García Ruiz, BegoñaUBU authority Orcid
    Publicado en
    Chemistry-a european journal. 2018, V. 24, n. 44, p. 11292-11296
    Editorial
    Wiley-VCH Verlag
    Fecha de publicación
    2018-08
    ISSN
    0947-6539
    DOI
    10.1002/chem.201802365
    Abstract
    A new fluorescent, non‐cytotoxic perylene diimide derivative with two biotins at the peri position, PDI2B, has been synthesized. This molecule is able to interact selectively with G‐quadruplexes with scarce or no affinity towards single‐ or double‐stranded DNA. These features have made it possible to design a simple, effective, safe, cheap, and selective method for fishing G‐quadruplex structures in solution by use of PDI2B and streptavidin coated magnetic beads. The new cyclic method reported leads to the recovery of more than 80 % of G‐quadruplex structures from solution, even in the presence of an excess of single‐stranded or duplex DNA as competitors. Moreover, PDI2B is a G4 ligand that can display higher thermal stabilization and greater affinity for 2‐ over 3‐tetrad quadruplexes, which constitutes a novel type of behavior.
    Materia
    Química
    Chemistry
    URI
    http://hdl.handle.net/10259/4882
    Versión del editor
    https://doi.org/10.1002/chem.201802365
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