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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/6124

    Título
    Derivative UV/Vis spectroelectrochemistry in a thin-layer regime: deconvolution and simultaneous quantification of ascorbic acid, dopamine and uric acid
    Autor
    Olmo Alonso, Fabiola
    Garoz Ruiz, JesúsUBU authority
    Colina Santamaría, ÁlvaroUBU authority
    Heras Vidaurre, AránzazuUBU authority
    Publicado en
    Analytical and Bioanalytical Chemistry. 2020, V. 412, n. 24, p. 6329–6339
    Editorial
    Springer
    Fecha de publicación
    2020-09
    ISSN
    1618-2642
    DOI
    10.1007/s00216-020-02564-1
    Abstract
    In this work, UV/Vis spectroelectrochemistry (SEC), in a thin-layer regime and parallel configuration, is selected to solve a complex mixture that contains dopamine (DA), ascorbic acid (AA) and uric acid (UA). These molecules, like many other biological compounds, are assuming a highly important place in analytical and biomedical fields due to the fundamental role that they play in human metabolism. In addition, low or high levels of these compounds are associated with diseases such as Parkinson’s disease. For this reason, the quantification of these biomolecules is becoming increasingly critical. However, some drawbacks must be overcome, because the three molecules coexist in the human body, and the species are subject to mutual interference. In fact, they are all oxidized at similar potentials, and their UV/Vis absorption bands overlap, greatly complicating their quantification. For this reason, derivative SEC together with suitable chemometric tools such as PARAFAC are proposed to solve this complex matrix. This technique allows us to separate the contribution of each of these molecules present in a sample and to quantify all of them, achieving high resolution and reproducibility. Besides, detection limits at the micromolar level are achieved for DA, AA and UA in mixture solutions. This work thus demonstrates the great potential for derivative potentiodynamic SEC combined with the appropriate chemometric tools in solving complex mixtures, a field where SEC is still taking the first steps.
    Palabras clave
    Spectroelectrochemistry
    PARAFAC
    Quantitative analysis
    Derivative of absorbance with respect towavelength
    Materia
    Química analítica
    Chemistry, Analytic
    URI
    http://hdl.handle.net/10259/6124
    Versión del editor
    https://doi.org/10.1007/s00216-020-02564-1
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