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Título
Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs
Autor
Publicado en
Organic & Biomolecular Chemistry. 2014, V. 12, n. 11, p. 1771-1778
Editorial
Royal Society of Chemistry
Fecha de publicación
2014-03
ISSN
1477-0520
DOI
10.1039/c3ob42341g
Zusammenfassung
Ten synthetic analogs of the marine alkaloids tambjamines, bearing aromatic enamine moieties, have
been synthesized. These compounds proved to be highly efficient transmembrane anion transporters in
model liposomes. Changes in the electronic nature of the substituents of the aromatic enamine or the
alkoxy group of the central pyrrole group did not affect this anionophore activity. The in vitro activity of
these compounds has also been studied. They trigger apoptosis in several cancer cell lines with IC50
values in the low micromolar range as well as modify the intracellular pH, inducing the basification of
acidic organelles.
Materia
Química orgánica
Chemistry, Organic
Versión del editor
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